Expression of prostaglandin I2 (prostacyclin) receptor in blood of migraine patients: A potential biomarker

BACKGROUND: Migraine is the most common chronic neurological disorders that may be associated with vasodilatation. According to the role of prostaglandin I2 (prostacyclin) receptor (PTGIR) in migraine as a receptor, which acts in vasodilatation, we decided to study the changes of PTGIR expression in...

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Detalles Bibliográficos
Autores principales: Kheirollahi, Majid, Kazemi, Mohammad, Amini, Gilda, Khorvash, Fariborz, Ahangari, Fatemeh, Kolahdouz, Mahsa, Koulivand, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513332/
https://www.ncbi.nlm.nih.gov/pubmed/26261823
http://dx.doi.org/10.4103/2277-9175.158030
Descripción
Sumario:BACKGROUND: Migraine is the most common chronic neurological disorders that may be associated with vasodilatation. According to the role of prostaglandin I2 (prostacyclin) receptor (PTGIR) in migraine as a receptor, which acts in vasodilatation, we decided to study the changes of PTGIR expression in migraine patients in relation to a suitable control group. MATERIALS AND METHODS: Extracted mRNA from lymphocytes of 50 cases and 50 controls was used to synthesize cDNA. Real-time polymerase chain reaction was performed, and the data were analyzed. Our results show that PTGIR mRNA expression in cases was significantly higher than the control group (P = 0.010). RESULTS: In conclusion, mRNA expression of PTGIR in the blood of people with migraines could be considered as a biomarker. CONCLUSION: In addition, repression of PTGIR gene expression by methods such as using siRNA is probably suitable for therapy of migraine patients.

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