Hypoxia-inducible miR-182 enhances HIF1α signaling via targeting PHD2 and FIH1 in prostate cancer

Activation of hypoxia-inducible factor 1α (HIF1α) controls the transcription of genes governing angiogenesis under hypoxic condition during tumorigenesis. Here we show that hypoxia-responsive miR-182 is regulated by HIF1α at transcriptional level. Prolyl hydroxylase domain enzymes (PHD) and factor i...

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Detalles Bibliográficos
Autores principales: Li, Yan, Zhang, Duo, Wang, Xiaoyun, Yao, Xuan, Ye, Cheng, Zhang, Shengjie, Wang, Hui, Chang, Cunjie, Xia, Hongfeng, Wang, Yu-cheng, Fang, Jing, Yan, Jun, Ying, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513346/
https://www.ncbi.nlm.nih.gov/pubmed/26205124
http://dx.doi.org/10.1038/srep12495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513346/
https://www.ncbi.nlm.nih.gov/pubmed/26205124
http://dx.doi.org/10.1038/srep12495

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