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BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1
B-cell translocation gene 1 (BTG1) is a member of the BTG/transducer of Erb family. BTG1 regulates cell cycle progression, inhibits proliferation, promotes apoptosis and stimulates cellular differentiation in multiple cell types. However, the functions of BTG1 in renal cell carcinoma (RCC) remain un...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513370/ https://www.ncbi.nlm.nih.gov/pubmed/26622543 http://dx.doi.org/10.3892/ol.2015.3293 |
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author | LIU, CHUNHUI TAO, TAO XU, BIN LU, KAI ZHANG, LEI JIANG, LIANG CHEN, SHUQIU LIU, DACHUANG ZHANG, XIAOWEN CAO, NIHAO CHEN, MING |
author_facet | LIU, CHUNHUI TAO, TAO XU, BIN LU, KAI ZHANG, LEI JIANG, LIANG CHEN, SHUQIU LIU, DACHUANG ZHANG, XIAOWEN CAO, NIHAO CHEN, MING |
author_sort | LIU, CHUNHUI |
collection | PubMed |
description | B-cell translocation gene 1 (BTG1) is a member of the BTG/transducer of Erb family. BTG1 regulates cell cycle progression, inhibits proliferation, promotes apoptosis and stimulates cellular differentiation in multiple cell types. However, the functions of BTG1 in renal cell carcinoma (RCC) remain unclear. Therefore, the present study investigated the role of BTG1 in RCC tissue samples and 786-O RCC cells. RCC tissues and cells exhibited significantly weaker BTG1 protein and mRNA expression compared with para-carcinoma control tissues (P<0.05). Upregulated BTG1 expression induced significant G0/G1 cell cycle arrest, apoptosis and inhibition of cell proliferation in 786-O cells (P<0.05). Furthermore, BTG1 interacted with protein arginine N-methyltransferase 1 (PRMT1), and blocking the action of PRMT1 in 786-O cells resulted in inhibition of BTG1 function. These findings indicate that BTG1 may inhibit cell growth and promote apoptosis by interacting with PRMT1 in RCC; the identification of this mechanism may aid in the production of novel therapies for RCC. |
format | Online Article Text |
id | pubmed-4513370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-45133702015-11-30 BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1 LIU, CHUNHUI TAO, TAO XU, BIN LU, KAI ZHANG, LEI JIANG, LIANG CHEN, SHUQIU LIU, DACHUANG ZHANG, XIAOWEN CAO, NIHAO CHEN, MING Oncol Lett Articles B-cell translocation gene 1 (BTG1) is a member of the BTG/transducer of Erb family. BTG1 regulates cell cycle progression, inhibits proliferation, promotes apoptosis and stimulates cellular differentiation in multiple cell types. However, the functions of BTG1 in renal cell carcinoma (RCC) remain unclear. Therefore, the present study investigated the role of BTG1 in RCC tissue samples and 786-O RCC cells. RCC tissues and cells exhibited significantly weaker BTG1 protein and mRNA expression compared with para-carcinoma control tissues (P<0.05). Upregulated BTG1 expression induced significant G0/G1 cell cycle arrest, apoptosis and inhibition of cell proliferation in 786-O cells (P<0.05). Furthermore, BTG1 interacted with protein arginine N-methyltransferase 1 (PRMT1), and blocking the action of PRMT1 in 786-O cells resulted in inhibition of BTG1 function. These findings indicate that BTG1 may inhibit cell growth and promote apoptosis by interacting with PRMT1 in RCC; the identification of this mechanism may aid in the production of novel therapies for RCC. D.A. Spandidos 2015-08 2015-05-29 /pmc/articles/PMC4513370/ /pubmed/26622543 http://dx.doi.org/10.3892/ol.2015.3293 Text en Copyright: © Liu et al. This is an open access article distributed under the terms of a Creative Commons Attribution License. http://creativecommons.org/licenses/by/4.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles LIU, CHUNHUI TAO, TAO XU, BIN LU, KAI ZHANG, LEI JIANG, LIANG CHEN, SHUQIU LIU, DACHUANG ZHANG, XIAOWEN CAO, NIHAO CHEN, MING BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1 |
title | BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1 |
title_full | BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1 |
title_fullStr | BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1 |
title_full_unstemmed | BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1 |
title_short | BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1 |
title_sort | btg1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with prmt1 |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513370/ https://www.ncbi.nlm.nih.gov/pubmed/26622543 http://dx.doi.org/10.3892/ol.2015.3293 |
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