The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription

BACKGROUND: The Chines herb derived Sparstolonin B, (SsnB), is a recently identified natural compound that selectively blocks TLR2- and TLR4-mediated inflammatory signaling. But it is unknown whether this compound has any effect on HIV infection. FINDINGS: We found that SsnB treatment blocked HIV-1...

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Autores principales: Deng, Xin, Zhang, Yaping, Jiang, Feng, Chen, Ran, Peng, Peichun, Wen, Bin, Liang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513614/
https://www.ncbi.nlm.nih.gov/pubmed/26206295
http://dx.doi.org/10.1186/s12985-015-0339-8
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author Deng, Xin
Zhang, Yaping
Jiang, Feng
Chen, Ran
Peng, Peichun
Wen, Bin
Liang, Jian
author_facet Deng, Xin
Zhang, Yaping
Jiang, Feng
Chen, Ran
Peng, Peichun
Wen, Bin
Liang, Jian
author_sort Deng, Xin
collection PubMed
description BACKGROUND: The Chines herb derived Sparstolonin B, (SsnB), is a recently identified natural compound that selectively blocks TLR2- and TLR4-mediated inflammatory signaling. But it is unknown whether this compound has any effect on HIV infection. FINDINGS: We found that SsnB treatment blocked HIV-1 transcription via a novel mechanism that requires the TAR region. Treatment of human T cell lines or peripheral blood mononuclear cells with SsnB at 1 μM significantly inhibited HIV production. Lastly, SsnB was able to inhibit HIV in synergy with AZT. CONCLUSIONS: These data suggest that SsnB is a novel natural compound that inhibits HIV-1 transcription and may be a new drug in the treatment of HIV infection.
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spelling pubmed-45136142015-07-25 The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription Deng, Xin Zhang, Yaping Jiang, Feng Chen, Ran Peng, Peichun Wen, Bin Liang, Jian Virol J Short Report BACKGROUND: The Chines herb derived Sparstolonin B, (SsnB), is a recently identified natural compound that selectively blocks TLR2- and TLR4-mediated inflammatory signaling. But it is unknown whether this compound has any effect on HIV infection. FINDINGS: We found that SsnB treatment blocked HIV-1 transcription via a novel mechanism that requires the TAR region. Treatment of human T cell lines or peripheral blood mononuclear cells with SsnB at 1 μM significantly inhibited HIV production. Lastly, SsnB was able to inhibit HIV in synergy with AZT. CONCLUSIONS: These data suggest that SsnB is a novel natural compound that inhibits HIV-1 transcription and may be a new drug in the treatment of HIV infection. BioMed Central 2015-07-25 /pmc/articles/PMC4513614/ /pubmed/26206295 http://dx.doi.org/10.1186/s12985-015-0339-8 Text en © Deng et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Deng, Xin
Zhang, Yaping
Jiang, Feng
Chen, Ran
Peng, Peichun
Wen, Bin
Liang, Jian
The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription
title The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription
title_full The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription
title_fullStr The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription
title_full_unstemmed The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription
title_short The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription
title_sort chinese herb-derived sparstolonin b suppresses hiv-1 transcription
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513614/
https://www.ncbi.nlm.nih.gov/pubmed/26206295
http://dx.doi.org/10.1186/s12985-015-0339-8
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