TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma

BACKGROUND: Transforming growth factor (TGF)-β is involved in many physiologic processes, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we analyzed the correlation between transforming growth factor beta 1 (TGF-β1) expression and progn...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yijie, Ma, Lin, He, Qian, Zhang, Shaobo, Zhang, Chenghua, Jia, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513632/
https://www.ncbi.nlm.nih.gov/pubmed/25993985
http://dx.doi.org/10.1186/s40659-015-0016-9
_version_ 1782382675660636160
author Chen, Yijie
Ma, Lin
He, Qian
Zhang, Shaobo
Zhang, Chenghua
Jia, Wei
author_facet Chen, Yijie
Ma, Lin
He, Qian
Zhang, Shaobo
Zhang, Chenghua
Jia, Wei
author_sort Chen, Yijie
collection PubMed
description BACKGROUND: Transforming growth factor (TGF)-β is involved in many physiologic processes, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we analyzed the correlation between transforming growth factor beta 1 (TGF-β1) expression and prognosis in intrahepatic cholangiocarcinoma. RESULTS: We examined the expression of TGF-β1 in 78 intrahepatic cholangiocarcinomas by immunohistochemistry and correlated the expression with clinicopathological parameters. TGF-β1 was expressed in 37 of 78 (47.4 %) intrahepatic cholangiocarcinomas. The expression of TGF-β1 was significantly correlated with lymph node metastasis, distant metastasis, and tumour recurrence. Patients with TGF-β1-positive tumours had significantly shorter survival time. In a multivariant analysis, the expression of TGF-β1 and the tumour stage were independent prognostic factors. CONCLUSIONS: Our data suggest that expression of TGF-β1 is a novel prognostic marker for intrahepatic cholangiocarcinoma.
format Online
Article
Text
id pubmed-4513632
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-45136322015-07-25 TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma Chen, Yijie Ma, Lin He, Qian Zhang, Shaobo Zhang, Chenghua Jia, Wei Biol Res Research Article BACKGROUND: Transforming growth factor (TGF)-β is involved in many physiologic processes, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we analyzed the correlation between transforming growth factor beta 1 (TGF-β1) expression and prognosis in intrahepatic cholangiocarcinoma. RESULTS: We examined the expression of TGF-β1 in 78 intrahepatic cholangiocarcinomas by immunohistochemistry and correlated the expression with clinicopathological parameters. TGF-β1 was expressed in 37 of 78 (47.4 %) intrahepatic cholangiocarcinomas. The expression of TGF-β1 was significantly correlated with lymph node metastasis, distant metastasis, and tumour recurrence. Patients with TGF-β1-positive tumours had significantly shorter survival time. In a multivariant analysis, the expression of TGF-β1 and the tumour stage were independent prognostic factors. CONCLUSIONS: Our data suggest that expression of TGF-β1 is a novel prognostic marker for intrahepatic cholangiocarcinoma. BioMed Central 2015-05-21 /pmc/articles/PMC4513632/ /pubmed/25993985 http://dx.doi.org/10.1186/s40659-015-0016-9 Text en © Chen et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Chen, Yijie
Ma, Lin
He, Qian
Zhang, Shaobo
Zhang, Chenghua
Jia, Wei
TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma
title TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma
title_full TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma
title_fullStr TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma
title_full_unstemmed TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma
title_short TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma
title_sort tgf-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513632/
https://www.ncbi.nlm.nih.gov/pubmed/25993985
http://dx.doi.org/10.1186/s40659-015-0016-9
work_keys_str_mv AT chenyijie tgfb1expressionisassociatedwithinvasionandmetastasisofintrahepaticcholangiocarcinoma
AT malin tgfb1expressionisassociatedwithinvasionandmetastasisofintrahepaticcholangiocarcinoma
AT heqian tgfb1expressionisassociatedwithinvasionandmetastasisofintrahepaticcholangiocarcinoma
AT zhangshaobo tgfb1expressionisassociatedwithinvasionandmetastasisofintrahepaticcholangiocarcinoma
AT zhangchenghua tgfb1expressionisassociatedwithinvasionandmetastasisofintrahepaticcholangiocarcinoma
AT jiawei tgfb1expressionisassociatedwithinvasionandmetastasisofintrahepaticcholangiocarcinoma

Ejemplares similares