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Gender-Specific Differences in Surgical Site Infections: An Analysis of 438,050 Surgical Procedures from the German National Nosocomial Infections Surveillance System

BACKGROUND: Surgical site infections (SSI) are among the most frequent healthcare-associated infections. They impose a substantial burden with increased morbidity and exceeding healthcare costs. Risk factors such as age, diabetes, and smoking status are commonly accounted for in the literature, but...

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Autores principales: Langelotz, Corinna, Mueller-Rau, Carolin, Terziyski, Stoil, Rau, Beate, Krannich, Alexander, Gastmeier, Petra, Geffers, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger Verlag für Medizin und Naturwissenschaften GmbH 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513817/
https://www.ncbi.nlm.nih.gov/pubmed/26288585
http://dx.doi.org/10.1159/000362100
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author Langelotz, Corinna
Mueller-Rau, Carolin
Terziyski, Stoil
Rau, Beate
Krannich, Alexander
Gastmeier, Petra
Geffers, Christine
author_facet Langelotz, Corinna
Mueller-Rau, Carolin
Terziyski, Stoil
Rau, Beate
Krannich, Alexander
Gastmeier, Petra
Geffers, Christine
author_sort Langelotz, Corinna
collection PubMed
description BACKGROUND: Surgical site infections (SSI) are among the most frequent healthcare-associated infections. They impose a substantial burden with increased morbidity and exceeding healthcare costs. Risk factors such as age, diabetes, and smoking status are commonly accounted for in the literature, but few studies address gender differences. METHODS: Data from the German Nosocomial Infections Surveillance System (Krankenhaus-Infektions-Surveillance-System (KISS)) from 2005 to 2010 were analysed for cardiac, vascular, visceral, and orthopaedic surgery, with a total of 438,050 surgical procedures and 8,639 SSI. Rates of SSI and isolated pathogens were analysed for gender. RESULTS: Women had a lower rate of SSI (SSI/100 procedures) in abdominal surgery than men (2.92 vs. 4.37; p < 0.001). No gender-specific differences were found in orthopaedic and vascular surgery, while women had a higher risk for SSI in cardiac surgery (5.50 vs. 3.02; p < 0.001). Isolated pathogens showed differences for sensitive Staphylococcus aureus and Pseudomonas aeruginosa, which were more frequent in women (both p = 0.007), while coagulase-negative staphylococci occurred more often in men (18.8 vs. 14.0%; p < 0.001). CONCLUSION: Gender differences in SSI exist and are procedure-specific. The underlying mechanisms need to be further elucidated so that targeted measures for the prevention of SSI can be developed.
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spelling pubmed-45138172015-08-18 Gender-Specific Differences in Surgical Site Infections: An Analysis of 438,050 Surgical Procedures from the German National Nosocomial Infections Surveillance System Langelotz, Corinna Mueller-Rau, Carolin Terziyski, Stoil Rau, Beate Krannich, Alexander Gastmeier, Petra Geffers, Christine Viszeralmedizin Original Article · Originalarbeit BACKGROUND: Surgical site infections (SSI) are among the most frequent healthcare-associated infections. They impose a substantial burden with increased morbidity and exceeding healthcare costs. Risk factors such as age, diabetes, and smoking status are commonly accounted for in the literature, but few studies address gender differences. METHODS: Data from the German Nosocomial Infections Surveillance System (Krankenhaus-Infektions-Surveillance-System (KISS)) from 2005 to 2010 were analysed for cardiac, vascular, visceral, and orthopaedic surgery, with a total of 438,050 surgical procedures and 8,639 SSI. Rates of SSI and isolated pathogens were analysed for gender. RESULTS: Women had a lower rate of SSI (SSI/100 procedures) in abdominal surgery than men (2.92 vs. 4.37; p < 0.001). No gender-specific differences were found in orthopaedic and vascular surgery, while women had a higher risk for SSI in cardiac surgery (5.50 vs. 3.02; p < 0.001). Isolated pathogens showed differences for sensitive Staphylococcus aureus and Pseudomonas aeruginosa, which were more frequent in women (both p = 0.007), while coagulase-negative staphylococci occurred more often in men (18.8 vs. 14.0%; p < 0.001). CONCLUSION: Gender differences in SSI exist and are procedure-specific. The underlying mechanisms need to be further elucidated so that targeted measures for the prevention of SSI can be developed. S. Karger Verlag für Medizin und Naturwissenschaften GmbH 2014-04 2014-03-28 /pmc/articles/PMC4513817/ /pubmed/26288585 http://dx.doi.org/10.1159/000362100 Text en Copyright © 2014 by S. Karger GmbH, Freiburg
spellingShingle Original Article · Originalarbeit
Langelotz, Corinna
Mueller-Rau, Carolin
Terziyski, Stoil
Rau, Beate
Krannich, Alexander
Gastmeier, Petra
Geffers, Christine
Gender-Specific Differences in Surgical Site Infections: An Analysis of 438,050 Surgical Procedures from the German National Nosocomial Infections Surveillance System
title Gender-Specific Differences in Surgical Site Infections: An Analysis of 438,050 Surgical Procedures from the German National Nosocomial Infections Surveillance System
title_full Gender-Specific Differences in Surgical Site Infections: An Analysis of 438,050 Surgical Procedures from the German National Nosocomial Infections Surveillance System
title_fullStr Gender-Specific Differences in Surgical Site Infections: An Analysis of 438,050 Surgical Procedures from the German National Nosocomial Infections Surveillance System
title_full_unstemmed Gender-Specific Differences in Surgical Site Infections: An Analysis of 438,050 Surgical Procedures from the German National Nosocomial Infections Surveillance System
title_short Gender-Specific Differences in Surgical Site Infections: An Analysis of 438,050 Surgical Procedures from the German National Nosocomial Infections Surveillance System
title_sort gender-specific differences in surgical site infections: an analysis of 438,050 surgical procedures from the german national nosocomial infections surveillance system
topic Original Article · Originalarbeit
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513817/
https://www.ncbi.nlm.nih.gov/pubmed/26288585
http://dx.doi.org/10.1159/000362100
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