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Features of cardiomyocyte proliferation and its potential for cardiac regeneration

The human heart does not regenerate. Instead, following injury, human hearts scar. The loss of contractile tissue contributes significantly to morbidity and mortality. In contrast to humans, zebrafish and newts faithfully regenerate their hearts. Interestingly, regeneration is in both cases based on...

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Detalles Bibliográficos
Autores principales: van Amerongen, Machteld J, Engel, Felix B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514102/
https://www.ncbi.nlm.nih.gov/pubmed/18662194
http://dx.doi.org/10.1111/j.1582-4934.2008.00439.x
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author van Amerongen, Machteld J
Engel, Felix B
author_facet van Amerongen, Machteld J
Engel, Felix B
author_sort van Amerongen, Machteld J
collection PubMed
description The human heart does not regenerate. Instead, following injury, human hearts scar. The loss of contractile tissue contributes significantly to morbidity and mortality. In contrast to humans, zebrafish and newts faithfully regenerate their hearts. Interestingly, regeneration is in both cases based on cardiomyocyte proliferation. In addition, mammalian cardiomyocytes proliferate during foetal development. Their proliferation reaches its maximum around chamber formation, stops shortly after birth, and subsequent heart growth is mostly achieved by an increase in cardiomyocyte size (hypertrophy). The underlying mechanisms that regulate cell cycle arrest and the switch from proliferation to hypertrophy are unclear. In this review, we highlight features of dividing cardiomyocytes, summarize the attempts to induce mammalian cardiomyocyte proliferation, critically discuss methods commonly used for its detection, and explore the potential and problems of inducing cardiomyocyte proliferation to improve function in diseased hearts.
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spelling pubmed-45141022015-07-27 Features of cardiomyocyte proliferation and its potential for cardiac regeneration van Amerongen, Machteld J Engel, Felix B J Cell Mol Med Reviews The human heart does not regenerate. Instead, following injury, human hearts scar. The loss of contractile tissue contributes significantly to morbidity and mortality. In contrast to humans, zebrafish and newts faithfully regenerate their hearts. Interestingly, regeneration is in both cases based on cardiomyocyte proliferation. In addition, mammalian cardiomyocytes proliferate during foetal development. Their proliferation reaches its maximum around chamber formation, stops shortly after birth, and subsequent heart growth is mostly achieved by an increase in cardiomyocyte size (hypertrophy). The underlying mechanisms that regulate cell cycle arrest and the switch from proliferation to hypertrophy are unclear. In this review, we highlight features of dividing cardiomyocytes, summarize the attempts to induce mammalian cardiomyocyte proliferation, critically discuss methods commonly used for its detection, and explore the potential and problems of inducing cardiomyocyte proliferation to improve function in diseased hearts. John Wiley & Sons, Ltd 2008-12 2008-07-26 /pmc/articles/PMC4514102/ /pubmed/18662194 http://dx.doi.org/10.1111/j.1582-4934.2008.00439.x Text en © 2008 The Authors Journal compilation © 2008 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
spellingShingle Reviews
van Amerongen, Machteld J
Engel, Felix B
Features of cardiomyocyte proliferation and its potential for cardiac regeneration
title Features of cardiomyocyte proliferation and its potential for cardiac regeneration
title_full Features of cardiomyocyte proliferation and its potential for cardiac regeneration
title_fullStr Features of cardiomyocyte proliferation and its potential for cardiac regeneration
title_full_unstemmed Features of cardiomyocyte proliferation and its potential for cardiac regeneration
title_short Features of cardiomyocyte proliferation and its potential for cardiac regeneration
title_sort features of cardiomyocyte proliferation and its potential for cardiac regeneration
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514102/
https://www.ncbi.nlm.nih.gov/pubmed/18662194
http://dx.doi.org/10.1111/j.1582-4934.2008.00439.x
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