Dasatinib Induced Avascular Necrosis of Femoral Head in Adult Patient with Chronic Myeloid Leukemia

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia (Ph) chromosome resulting from the reciprocal translocation t(9;22)(q34;q11). The molecular consequence of this translocation is the generation of the BCR–ABL fusion gene, which encodes...

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Autores principales: Yassin, Mohamed A, Moustafa, Abbas H, Nashwan, Abdulqadir J, Soliman, Ashraf T, El Derhoubi, Hatim, Mohamed, Shehab F, Mudawi, Deena S, ELkourashy, Sarah, Asaari, Deena-Raiza, Gutierrez, Hope-Love G, Hussein, Radwa M, Al Musharraf, Mohamed, Kohla, Samah, Elsayed, Ahmed, Al-Dewik, Nader
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514172/
https://www.ncbi.nlm.nih.gov/pubmed/26279632
http://dx.doi.org/10.4137/CMBD.S24628
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author Yassin, Mohamed A
Moustafa, Abbas H
Nashwan, Abdulqadir J
Soliman, Ashraf T
El Derhoubi, Hatim
Mohamed, Shehab F
Mudawi, Deena S
ELkourashy, Sarah
Asaari, Deena-Raiza
Gutierrez, Hope-Love G
Hussein, Radwa M
Al Musharraf, Mohamed
Kohla, Samah
Elsayed, Ahmed
Al-Dewik, Nader
author_facet Yassin, Mohamed A
Moustafa, Abbas H
Nashwan, Abdulqadir J
Soliman, Ashraf T
El Derhoubi, Hatim
Mohamed, Shehab F
Mudawi, Deena S
ELkourashy, Sarah
Asaari, Deena-Raiza
Gutierrez, Hope-Love G
Hussein, Radwa M
Al Musharraf, Mohamed
Kohla, Samah
Elsayed, Ahmed
Al-Dewik, Nader
author_sort Yassin, Mohamed A
collection PubMed
description Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia (Ph) chromosome resulting from the reciprocal translocation t(9;22)(q34;q11). The molecular consequence of this translocation is the generation of the BCR–ABL fusion gene, which encodes a constitutively active protein tyrosine kinase. The oncogenic protein tyrosine kinase, which is located in the cytoplasm, is responsible for the leukemia phenotype through the constitutive activation of multiple signaling pathways involved in the cell cycle and in adhesion and apoptosis. Avascular necrosis of the femoral head (AVNFH) is not a specific disease. It occurs as a complication or secondary to various causes. These conditions probably lead to impaired blood supply to the femoral head. The diagnosis of AVNFH is based on clinical findings and is supported by specific radiological manifestations. We reported a case of a 34-year-old Sudanese female with CML who developed AVNFH after receiving dasatinib as a second-line therapy. Though the mechanism by which dasatinib can cause avascular necrosis (AVN) is not clear, it can be postulated because of microcirculatory obstruction of the femoral head. To the best of our knowledge and after extensive literature search, this is the first reported case of AVNFH induced by dasatinib in a patient with CML.
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spelling pubmed-45141722015-08-14 Dasatinib Induced Avascular Necrosis of Femoral Head in Adult Patient with Chronic Myeloid Leukemia Yassin, Mohamed A Moustafa, Abbas H Nashwan, Abdulqadir J Soliman, Ashraf T El Derhoubi, Hatim Mohamed, Shehab F Mudawi, Deena S ELkourashy, Sarah Asaari, Deena-Raiza Gutierrez, Hope-Love G Hussein, Radwa M Al Musharraf, Mohamed Kohla, Samah Elsayed, Ahmed Al-Dewik, Nader Clin Med Insights Blood Disord Case Report Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia (Ph) chromosome resulting from the reciprocal translocation t(9;22)(q34;q11). The molecular consequence of this translocation is the generation of the BCR–ABL fusion gene, which encodes a constitutively active protein tyrosine kinase. The oncogenic protein tyrosine kinase, which is located in the cytoplasm, is responsible for the leukemia phenotype through the constitutive activation of multiple signaling pathways involved in the cell cycle and in adhesion and apoptosis. Avascular necrosis of the femoral head (AVNFH) is not a specific disease. It occurs as a complication or secondary to various causes. These conditions probably lead to impaired blood supply to the femoral head. The diagnosis of AVNFH is based on clinical findings and is supported by specific radiological manifestations. We reported a case of a 34-year-old Sudanese female with CML who developed AVNFH after receiving dasatinib as a second-line therapy. Though the mechanism by which dasatinib can cause avascular necrosis (AVN) is not clear, it can be postulated because of microcirculatory obstruction of the femoral head. To the best of our knowledge and after extensive literature search, this is the first reported case of AVNFH induced by dasatinib in a patient with CML. Libertas Academica 2015-07-23 /pmc/articles/PMC4514172/ /pubmed/26279632 http://dx.doi.org/10.4137/CMBD.S24628 Text en © 2015 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Case Report
Yassin, Mohamed A
Moustafa, Abbas H
Nashwan, Abdulqadir J
Soliman, Ashraf T
El Derhoubi, Hatim
Mohamed, Shehab F
Mudawi, Deena S
ELkourashy, Sarah
Asaari, Deena-Raiza
Gutierrez, Hope-Love G
Hussein, Radwa M
Al Musharraf, Mohamed
Kohla, Samah
Elsayed, Ahmed
Al-Dewik, Nader
Dasatinib Induced Avascular Necrosis of Femoral Head in Adult Patient with Chronic Myeloid Leukemia
title Dasatinib Induced Avascular Necrosis of Femoral Head in Adult Patient with Chronic Myeloid Leukemia
title_full Dasatinib Induced Avascular Necrosis of Femoral Head in Adult Patient with Chronic Myeloid Leukemia
title_fullStr Dasatinib Induced Avascular Necrosis of Femoral Head in Adult Patient with Chronic Myeloid Leukemia
title_full_unstemmed Dasatinib Induced Avascular Necrosis of Femoral Head in Adult Patient with Chronic Myeloid Leukemia
title_short Dasatinib Induced Avascular Necrosis of Femoral Head in Adult Patient with Chronic Myeloid Leukemia
title_sort dasatinib induced avascular necrosis of femoral head in adult patient with chronic myeloid leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514172/
https://www.ncbi.nlm.nih.gov/pubmed/26279632
http://dx.doi.org/10.4137/CMBD.S24628
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