Cargando…

Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening

Surface topography has significant influence on good and fast osseointegration of biomedical implants. In this work, ultrasonic shot peening was conducted to modify titanium to produce nanograined (NG) surface. Its ability to induce new bone formation was evaluated using an in vivo animal model. We...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Yongyuan, Hu, Beibei, Tang, Chu, Wu, Yunpeng, Sun, Pengfei, Zhang, Xianlong, Jia, Yuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514313/
https://www.ncbi.nlm.nih.gov/pubmed/26229463
http://dx.doi.org/10.2147/IJN.S83788
_version_ 1782382754557591552
author Guo, Yongyuan
Hu, Beibei
Tang, Chu
Wu, Yunpeng
Sun, Pengfei
Zhang, Xianlong
Jia, Yuhua
author_facet Guo, Yongyuan
Hu, Beibei
Tang, Chu
Wu, Yunpeng
Sun, Pengfei
Zhang, Xianlong
Jia, Yuhua
author_sort Guo, Yongyuan
collection PubMed
description Surface topography has significant influence on good and fast osseointegration of biomedical implants. In this work, ultrasonic shot peening was conducted to modify titanium to produce nanograined (NG) surface. Its ability to induce new bone formation was evaluated using an in vivo animal model. We demonstrated that the NG surface enhanced osteoblast adhesion, proliferation, differentiation, and mineralization in in vitro experiments compared to coarse-grained titanium surface. Push-out test, histological observations, fluorescent labeling, and histomorphometrical analysis consistently indicated that the NG surfaces developed have the higher osseointegration than coarse-grained surfaces. Those results suggest that ultrasonic shot peening has the potential for future use as a surface modification method in biomedical application.
format Online
Article
Text
id pubmed-4514313
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-45143132015-07-30 Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening Guo, Yongyuan Hu, Beibei Tang, Chu Wu, Yunpeng Sun, Pengfei Zhang, Xianlong Jia, Yuhua Int J Nanomedicine Original Research Surface topography has significant influence on good and fast osseointegration of biomedical implants. In this work, ultrasonic shot peening was conducted to modify titanium to produce nanograined (NG) surface. Its ability to induce new bone formation was evaluated using an in vivo animal model. We demonstrated that the NG surface enhanced osteoblast adhesion, proliferation, differentiation, and mineralization in in vitro experiments compared to coarse-grained titanium surface. Push-out test, histological observations, fluorescent labeling, and histomorphometrical analysis consistently indicated that the NG surfaces developed have the higher osseointegration than coarse-grained surfaces. Those results suggest that ultrasonic shot peening has the potential for future use as a surface modification method in biomedical application. Dove Medical Press 2015-07-20 /pmc/articles/PMC4514313/ /pubmed/26229463 http://dx.doi.org/10.2147/IJN.S83788 Text en © 2015 Guo et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Guo, Yongyuan
Hu, Beibei
Tang, Chu
Wu, Yunpeng
Sun, Pengfei
Zhang, Xianlong
Jia, Yuhua
Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
title Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
title_full Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
title_fullStr Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
title_full_unstemmed Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
title_short Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
title_sort increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514313/
https://www.ncbi.nlm.nih.gov/pubmed/26229463
http://dx.doi.org/10.2147/IJN.S83788
work_keys_str_mv AT guoyongyuan increasedosteoblastfunctioninvitroandinvivothroughsurfacenanostructuringbyultrasonicshotpeening
AT hubeibei increasedosteoblastfunctioninvitroandinvivothroughsurfacenanostructuringbyultrasonicshotpeening
AT tangchu increasedosteoblastfunctioninvitroandinvivothroughsurfacenanostructuringbyultrasonicshotpeening
AT wuyunpeng increasedosteoblastfunctioninvitroandinvivothroughsurfacenanostructuringbyultrasonicshotpeening
AT sunpengfei increasedosteoblastfunctioninvitroandinvivothroughsurfacenanostructuringbyultrasonicshotpeening
AT zhangxianlong increasedosteoblastfunctioninvitroandinvivothroughsurfacenanostructuringbyultrasonicshotpeening
AT jiayuhua increasedosteoblastfunctioninvitroandinvivothroughsurfacenanostructuringbyultrasonicshotpeening