Cargando…
Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection
Patient: Male, 32 Final Diagnosis: MSSA pneumonia Symptoms: Cough • dyspnea • fever Medication: Meropenem • levofloxacin • vancomycin • peramivir Clinical Procedure: Diagnosed based on CT images • sputum culture • PCR Specialty: Infectious Diseases OBJECTIVE: Rare disease BACKGROUND: Increasing evid...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514331/ https://www.ncbi.nlm.nih.gov/pubmed/26171835 http://dx.doi.org/10.12659/AJCR.894022 |
_version_ | 1782382757244043264 |
---|---|
author | Masaki, Katsunori Ishii, Makoto Anraku, Masaki Namkoong, Ho Miyakawa, Ryo Nakajima, Takeshi Fukunaga, Koichi Naoki, Katsuhiko Tasaka, Sadatomo Soejima, Kenzo Sayama, Koichi Sugita, Kayoko Iwata, Satoshi Cui, Longzhu Hanaki, Hideaki Hasegawa, Naoki Betsuyaku, Tomoko |
author_facet | Masaki, Katsunori Ishii, Makoto Anraku, Masaki Namkoong, Ho Miyakawa, Ryo Nakajima, Takeshi Fukunaga, Koichi Naoki, Katsuhiko Tasaka, Sadatomo Soejima, Kenzo Sayama, Koichi Sugita, Kayoko Iwata, Satoshi Cui, Longzhu Hanaki, Hideaki Hasegawa, Naoki Betsuyaku, Tomoko |
author_sort | Masaki, Katsunori |
collection | PubMed |
description | Patient: Male, 32 Final Diagnosis: MSSA pneumonia Symptoms: Cough • dyspnea • fever Medication: Meropenem • levofloxacin • vancomycin • peramivir Clinical Procedure: Diagnosed based on CT images • sputum culture • PCR Specialty: Infectious Diseases OBJECTIVE: Rare disease BACKGROUND: Increasing evidence has indicated that Staphylococcus aureus pneumonia complicated with influenza virus infection is often fatal. In these cases, disease severity is typically determined by susceptibility to antimicrobial agents and the presence of high-virulence factors that are produced by Staphylococcus aureus, such as Panton-Valentine leukocidin (PVL). CASE REPORT: We describe a rare case of fatal community-acquired pneumonia caused by methicillin-sensitive Staphylococcus aureus (MSSA), which did not secrete major high-virulence factors and coexisted with influenza type B infection. The 32-year-old previously healthy male patient presented with dyspnea, high fever, and cough. His roommate had been diagnosed with influenza B virus infection 3 days earlier. Gram-positive clusters of cocci were detected in the patient’s sputum; therefore, he was diagnosed with severe pneumonia and septic shock, and was admitted to the intensive care unit. Despite intensive antibiotic and antiviral treatment, he died of multiple organ failure 5 days after admission. His blood culture from the admission was positive for MSSA, and further analysis revealed that the strain was negative for major high-virulence factors, including PVL and enterotoxins, although influenza B virus RNA was detected by PCR. CONCLUSIONS: Physicians should pay special attention to patients with pneumonia following influenza and Staphylococcus aureus infection, as it may be fatal, even if the Staphylococcus aureus strain is PVL-negative and sensitive to antimicrobial agents. |
format | Online Article Text |
id | pubmed-4514331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-45143312015-08-06 Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection Masaki, Katsunori Ishii, Makoto Anraku, Masaki Namkoong, Ho Miyakawa, Ryo Nakajima, Takeshi Fukunaga, Koichi Naoki, Katsuhiko Tasaka, Sadatomo Soejima, Kenzo Sayama, Koichi Sugita, Kayoko Iwata, Satoshi Cui, Longzhu Hanaki, Hideaki Hasegawa, Naoki Betsuyaku, Tomoko Am J Case Rep Articles Patient: Male, 32 Final Diagnosis: MSSA pneumonia Symptoms: Cough • dyspnea • fever Medication: Meropenem • levofloxacin • vancomycin • peramivir Clinical Procedure: Diagnosed based on CT images • sputum culture • PCR Specialty: Infectious Diseases OBJECTIVE: Rare disease BACKGROUND: Increasing evidence has indicated that Staphylococcus aureus pneumonia complicated with influenza virus infection is often fatal. In these cases, disease severity is typically determined by susceptibility to antimicrobial agents and the presence of high-virulence factors that are produced by Staphylococcus aureus, such as Panton-Valentine leukocidin (PVL). CASE REPORT: We describe a rare case of fatal community-acquired pneumonia caused by methicillin-sensitive Staphylococcus aureus (MSSA), which did not secrete major high-virulence factors and coexisted with influenza type B infection. The 32-year-old previously healthy male patient presented with dyspnea, high fever, and cough. His roommate had been diagnosed with influenza B virus infection 3 days earlier. Gram-positive clusters of cocci were detected in the patient’s sputum; therefore, he was diagnosed with severe pneumonia and septic shock, and was admitted to the intensive care unit. Despite intensive antibiotic and antiviral treatment, he died of multiple organ failure 5 days after admission. His blood culture from the admission was positive for MSSA, and further analysis revealed that the strain was negative for major high-virulence factors, including PVL and enterotoxins, although influenza B virus RNA was detected by PCR. CONCLUSIONS: Physicians should pay special attention to patients with pneumonia following influenza and Staphylococcus aureus infection, as it may be fatal, even if the Staphylococcus aureus strain is PVL-negative and sensitive to antimicrobial agents. International Scientific Literature, Inc. 2015-07-14 /pmc/articles/PMC4514331/ /pubmed/26171835 http://dx.doi.org/10.12659/AJCR.894022 Text en © Am J Case Rep, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Articles Masaki, Katsunori Ishii, Makoto Anraku, Masaki Namkoong, Ho Miyakawa, Ryo Nakajima, Takeshi Fukunaga, Koichi Naoki, Katsuhiko Tasaka, Sadatomo Soejima, Kenzo Sayama, Koichi Sugita, Kayoko Iwata, Satoshi Cui, Longzhu Hanaki, Hideaki Hasegawa, Naoki Betsuyaku, Tomoko Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection |
title | Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection |
title_full | Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection |
title_fullStr | Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection |
title_full_unstemmed | Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection |
title_short | Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection |
title_sort | fatal fulminant pneumonia caused by methicillin-sensitive staphylococcus aureus negative for major high-virulence factors following influenza b virus infection |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514331/ https://www.ncbi.nlm.nih.gov/pubmed/26171835 http://dx.doi.org/10.12659/AJCR.894022 |
work_keys_str_mv | AT masakikatsunori fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT ishiimakoto fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT anrakumasaki fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT namkoongho fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT miyakawaryo fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT nakajimatakeshi fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT fukunagakoichi fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT naokikatsuhiko fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT tasakasadatomo fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT soejimakenzo fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT sayamakoichi fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT sugitakayoko fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT iwatasatoshi fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT cuilongzhu fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT hanakihideaki fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT hasegawanaoki fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection AT betsuyakutomoko fatalfulminantpneumoniacausedbymethicillinsensitivestaphylococcusaureusnegativeformajorhighvirulencefactorsfollowinginfluenzabvirusinfection |