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Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection

Patient: Male, 32 Final Diagnosis: MSSA pneumonia Symptoms: Cough • dyspnea • fever Medication: Meropenem • levofloxacin • vancomycin • peramivir Clinical Procedure: Diagnosed based on CT images • sputum culture • PCR Specialty: Infectious Diseases OBJECTIVE: Rare disease BACKGROUND: Increasing evid...

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Autores principales: Masaki, Katsunori, Ishii, Makoto, Anraku, Masaki, Namkoong, Ho, Miyakawa, Ryo, Nakajima, Takeshi, Fukunaga, Koichi, Naoki, Katsuhiko, Tasaka, Sadatomo, Soejima, Kenzo, Sayama, Koichi, Sugita, Kayoko, Iwata, Satoshi, Cui, Longzhu, Hanaki, Hideaki, Hasegawa, Naoki, Betsuyaku, Tomoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514331/
https://www.ncbi.nlm.nih.gov/pubmed/26171835
http://dx.doi.org/10.12659/AJCR.894022
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author Masaki, Katsunori
Ishii, Makoto
Anraku, Masaki
Namkoong, Ho
Miyakawa, Ryo
Nakajima, Takeshi
Fukunaga, Koichi
Naoki, Katsuhiko
Tasaka, Sadatomo
Soejima, Kenzo
Sayama, Koichi
Sugita, Kayoko
Iwata, Satoshi
Cui, Longzhu
Hanaki, Hideaki
Hasegawa, Naoki
Betsuyaku, Tomoko
author_facet Masaki, Katsunori
Ishii, Makoto
Anraku, Masaki
Namkoong, Ho
Miyakawa, Ryo
Nakajima, Takeshi
Fukunaga, Koichi
Naoki, Katsuhiko
Tasaka, Sadatomo
Soejima, Kenzo
Sayama, Koichi
Sugita, Kayoko
Iwata, Satoshi
Cui, Longzhu
Hanaki, Hideaki
Hasegawa, Naoki
Betsuyaku, Tomoko
author_sort Masaki, Katsunori
collection PubMed
description Patient: Male, 32 Final Diagnosis: MSSA pneumonia Symptoms: Cough • dyspnea • fever Medication: Meropenem • levofloxacin • vancomycin • peramivir Clinical Procedure: Diagnosed based on CT images • sputum culture • PCR Specialty: Infectious Diseases OBJECTIVE: Rare disease BACKGROUND: Increasing evidence has indicated that Staphylococcus aureus pneumonia complicated with influenza virus infection is often fatal. In these cases, disease severity is typically determined by susceptibility to antimicrobial agents and the presence of high-virulence factors that are produced by Staphylococcus aureus, such as Panton-Valentine leukocidin (PVL). CASE REPORT: We describe a rare case of fatal community-acquired pneumonia caused by methicillin-sensitive Staphylococcus aureus (MSSA), which did not secrete major high-virulence factors and coexisted with influenza type B infection. The 32-year-old previously healthy male patient presented with dyspnea, high fever, and cough. His roommate had been diagnosed with influenza B virus infection 3 days earlier. Gram-positive clusters of cocci were detected in the patient’s sputum; therefore, he was diagnosed with severe pneumonia and septic shock, and was admitted to the intensive care unit. Despite intensive antibiotic and antiviral treatment, he died of multiple organ failure 5 days after admission. His blood culture from the admission was positive for MSSA, and further analysis revealed that the strain was negative for major high-virulence factors, including PVL and enterotoxins, although influenza B virus RNA was detected by PCR. CONCLUSIONS: Physicians should pay special attention to patients with pneumonia following influenza and Staphylococcus aureus infection, as it may be fatal, even if the Staphylococcus aureus strain is PVL-negative and sensitive to antimicrobial agents.
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spelling pubmed-45143312015-08-06 Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection Masaki, Katsunori Ishii, Makoto Anraku, Masaki Namkoong, Ho Miyakawa, Ryo Nakajima, Takeshi Fukunaga, Koichi Naoki, Katsuhiko Tasaka, Sadatomo Soejima, Kenzo Sayama, Koichi Sugita, Kayoko Iwata, Satoshi Cui, Longzhu Hanaki, Hideaki Hasegawa, Naoki Betsuyaku, Tomoko Am J Case Rep Articles Patient: Male, 32 Final Diagnosis: MSSA pneumonia Symptoms: Cough • dyspnea • fever Medication: Meropenem • levofloxacin • vancomycin • peramivir Clinical Procedure: Diagnosed based on CT images • sputum culture • PCR Specialty: Infectious Diseases OBJECTIVE: Rare disease BACKGROUND: Increasing evidence has indicated that Staphylococcus aureus pneumonia complicated with influenza virus infection is often fatal. In these cases, disease severity is typically determined by susceptibility to antimicrobial agents and the presence of high-virulence factors that are produced by Staphylococcus aureus, such as Panton-Valentine leukocidin (PVL). CASE REPORT: We describe a rare case of fatal community-acquired pneumonia caused by methicillin-sensitive Staphylococcus aureus (MSSA), which did not secrete major high-virulence factors and coexisted with influenza type B infection. The 32-year-old previously healthy male patient presented with dyspnea, high fever, and cough. His roommate had been diagnosed with influenza B virus infection 3 days earlier. Gram-positive clusters of cocci were detected in the patient’s sputum; therefore, he was diagnosed with severe pneumonia and septic shock, and was admitted to the intensive care unit. Despite intensive antibiotic and antiviral treatment, he died of multiple organ failure 5 days after admission. His blood culture from the admission was positive for MSSA, and further analysis revealed that the strain was negative for major high-virulence factors, including PVL and enterotoxins, although influenza B virus RNA was detected by PCR. CONCLUSIONS: Physicians should pay special attention to patients with pneumonia following influenza and Staphylococcus aureus infection, as it may be fatal, even if the Staphylococcus aureus strain is PVL-negative and sensitive to antimicrobial agents. International Scientific Literature, Inc. 2015-07-14 /pmc/articles/PMC4514331/ /pubmed/26171835 http://dx.doi.org/10.12659/AJCR.894022 Text en © Am J Case Rep, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Articles
Masaki, Katsunori
Ishii, Makoto
Anraku, Masaki
Namkoong, Ho
Miyakawa, Ryo
Nakajima, Takeshi
Fukunaga, Koichi
Naoki, Katsuhiko
Tasaka, Sadatomo
Soejima, Kenzo
Sayama, Koichi
Sugita, Kayoko
Iwata, Satoshi
Cui, Longzhu
Hanaki, Hideaki
Hasegawa, Naoki
Betsuyaku, Tomoko
Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection
title Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection
title_full Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection
title_fullStr Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection
title_full_unstemmed Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection
title_short Fatal Fulminant Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus Negative for Major High-Virulence Factors Following Influenza B Virus Infection
title_sort fatal fulminant pneumonia caused by methicillin-sensitive staphylococcus aureus negative for major high-virulence factors following influenza b virus infection
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514331/
https://www.ncbi.nlm.nih.gov/pubmed/26171835
http://dx.doi.org/10.12659/AJCR.894022
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