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Antituberculosis Drug Resistance Survey in Lesotho, 2008-2009: Lessons Learned
SETTING: Drug resistance is an increasing threat to tuberculosis (TB) control worldwide. The World Health Organization advises monitoring for drug resistance, with either ongoing surveillance or periodic surveys. METHODS: The antituberculosis drug resistance survey was conducted in Lesotho in 2008-2...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514631/ https://www.ncbi.nlm.nih.gov/pubmed/26207630 http://dx.doi.org/10.1371/journal.pone.0133808 |
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author | Maama-Maime, Llang B. Mareka, Mathabo Ershova, Julia V. Tlali, Thabong E. Kao, Kekeletso Phalatse, Mamakhetha Polansky, Lauren Beres, Laura K. Letsie, Moselinyane Holtz, Timothy H. |
author_facet | Maama-Maime, Llang B. Mareka, Mathabo Ershova, Julia V. Tlali, Thabong E. Kao, Kekeletso Phalatse, Mamakhetha Polansky, Lauren Beres, Laura K. Letsie, Moselinyane Holtz, Timothy H. |
author_sort | Maama-Maime, Llang B. |
collection | PubMed |
description | SETTING: Drug resistance is an increasing threat to tuberculosis (TB) control worldwide. The World Health Organization advises monitoring for drug resistance, with either ongoing surveillance or periodic surveys. METHODS: The antituberculosis drug resistance survey was conducted in Lesotho in 2008-2009. Basic demographic and TB history information was collected from individuals with positive sputum smear results at 17 diagnostic facilities. Additional sputum sample was sent to the national TB reference laboratory for culture and drug susceptibility testing. RESULTS: Among 3441 eligible smear-positive persons, 1121 (32.6%) were not requested to submit sputum for culture. Among 2320 persons submitted sputum, 1164 (50.2%) were not asked for clinical information or did not have valid sputum samples for testing. In addition, 445/2320 (19.2%) were excluded from analysis because of other laboratory or data management reasons. Among 984/3441 (28.6%) persons who had data available for analysis, MDR-TB was present in 24/773 (3.1%) of new and 25/195 (12.8%) of retreatment TB cases. Logistical, operational and data management challenges affected survey results. CONCLUSION: MDR-TB is prevalent in Lesotho, but limitations reduced the reliability of our findings. Multiple lessons learned during this survey can be applied to improve the next drug resistance survey in Lesotho and other resource constrained countries may learn how to avoid these bottlenecks. |
format | Online Article Text |
id | pubmed-4514631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45146312015-07-29 Antituberculosis Drug Resistance Survey in Lesotho, 2008-2009: Lessons Learned Maama-Maime, Llang B. Mareka, Mathabo Ershova, Julia V. Tlali, Thabong E. Kao, Kekeletso Phalatse, Mamakhetha Polansky, Lauren Beres, Laura K. Letsie, Moselinyane Holtz, Timothy H. PLoS One Research Article SETTING: Drug resistance is an increasing threat to tuberculosis (TB) control worldwide. The World Health Organization advises monitoring for drug resistance, with either ongoing surveillance or periodic surveys. METHODS: The antituberculosis drug resistance survey was conducted in Lesotho in 2008-2009. Basic demographic and TB history information was collected from individuals with positive sputum smear results at 17 diagnostic facilities. Additional sputum sample was sent to the national TB reference laboratory for culture and drug susceptibility testing. RESULTS: Among 3441 eligible smear-positive persons, 1121 (32.6%) were not requested to submit sputum for culture. Among 2320 persons submitted sputum, 1164 (50.2%) were not asked for clinical information or did not have valid sputum samples for testing. In addition, 445/2320 (19.2%) were excluded from analysis because of other laboratory or data management reasons. Among 984/3441 (28.6%) persons who had data available for analysis, MDR-TB was present in 24/773 (3.1%) of new and 25/195 (12.8%) of retreatment TB cases. Logistical, operational and data management challenges affected survey results. CONCLUSION: MDR-TB is prevalent in Lesotho, but limitations reduced the reliability of our findings. Multiple lessons learned during this survey can be applied to improve the next drug resistance survey in Lesotho and other resource constrained countries may learn how to avoid these bottlenecks. Public Library of Science 2015-07-24 /pmc/articles/PMC4514631/ /pubmed/26207630 http://dx.doi.org/10.1371/journal.pone.0133808 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
spellingShingle | Research Article Maama-Maime, Llang B. Mareka, Mathabo Ershova, Julia V. Tlali, Thabong E. Kao, Kekeletso Phalatse, Mamakhetha Polansky, Lauren Beres, Laura K. Letsie, Moselinyane Holtz, Timothy H. Antituberculosis Drug Resistance Survey in Lesotho, 2008-2009: Lessons Learned |
title | Antituberculosis Drug Resistance Survey in Lesotho, 2008-2009: Lessons Learned |
title_full | Antituberculosis Drug Resistance Survey in Lesotho, 2008-2009: Lessons Learned |
title_fullStr | Antituberculosis Drug Resistance Survey in Lesotho, 2008-2009: Lessons Learned |
title_full_unstemmed | Antituberculosis Drug Resistance Survey in Lesotho, 2008-2009: Lessons Learned |
title_short | Antituberculosis Drug Resistance Survey in Lesotho, 2008-2009: Lessons Learned |
title_sort | antituberculosis drug resistance survey in lesotho, 2008-2009: lessons learned |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514631/ https://www.ncbi.nlm.nih.gov/pubmed/26207630 http://dx.doi.org/10.1371/journal.pone.0133808 |
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