A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-Cells in Type 2 Diabetic Mice

The G protein-coupled receptor TGR5 is a membrane receptor for bile acids. Its agonism increases energy expenditure and controls blood glucose through secretion of glucagon-like peptide-1 in enteroendocrine cells. In this study, we explored the therapeutic potential of WB403, a small compound activa...

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Detalles Bibliográficos
Autores principales: Zheng, Chunbing, Zhou, Wenbo, Wang, Tongtong, You, Panpan, Zhao, Yongliang, Yang, Yiqing, Wang, Xin, Luo, Jian, Chen, Yihua, Liu, Mingyao, Chen, Huaqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514850/
https://www.ncbi.nlm.nih.gov/pubmed/26208278
http://dx.doi.org/10.1371/journal.pone.0134051

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