Massive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response

BACKGROUND: The presence of loss-of-heterozygosity (LOH) mutations in cancer cell genomes is commonly encountered. Moreover, the occurrences of LOHs in tumor suppressor genes play important roles in oncogenesis. However, because the causative mechanisms underlying LOH mutations in cancer cells yet r...

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Detalles Bibliográficos
Autores principales: Kumar, Yogesh, Yang, Jianfeng, Hu, Taobo, Chen, Lei, Xu, Zhi, Xu, Lin, Hu, Xiao-Xia, Tang, Gusheng, Wang, Jian-Min, Li, Yi, Poon, Wai-Sang, Wan, Weiqing, Zhang, Liwei, Mat, Wai-Kin, Pun, Frank W., Lee, Peggy, Cheong, Timothy H. Y., Ding, Xiaofan, Ng, Siu-Kin, Tsang, Shui-Ying, Chen, Jin-Fei, Zhang, Peng, Li, Shao, Wang, Hong-Yang, Xue, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515014/
https://www.ncbi.nlm.nih.gov/pubmed/26208496
http://dx.doi.org/10.1186/s12920-015-0104-2

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