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Acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial
BACKGROUND: The causes of chronic fatigue syndrome (CFS) and idiopathic chronic fatigue (ICF) are not clearly known, and there are no definitive treatments for them. Therefore, patients with CFS and ICF are interested in Oriental medicine or complementary and alternative medicine. For this reason, t...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515016/ https://www.ncbi.nlm.nih.gov/pubmed/26211002 http://dx.doi.org/10.1186/s13063-015-0857-0 |
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author | Kim, Jung-Eun Seo, Byung-Kwan Choi, Jin-Bong Kim, Hyeong-Jun Kim, Tae-Hun Lee, Min-Hee Kang, Kyung-Won Kim, Joo-Hee Shin, Kyung-Min Lee, Seunghoon Jung, So-Young Kim, Ae-Ran Shin, Mi-Suk Jung, Hee-Jung Park, Hyo-Ju Kim, Sung-Phil Baek, Yong-Hyeon Hong, Kwon-Eui Choi, Sun-Mi |
author_facet | Kim, Jung-Eun Seo, Byung-Kwan Choi, Jin-Bong Kim, Hyeong-Jun Kim, Tae-Hun Lee, Min-Hee Kang, Kyung-Won Kim, Joo-Hee Shin, Kyung-Min Lee, Seunghoon Jung, So-Young Kim, Ae-Ran Shin, Mi-Suk Jung, Hee-Jung Park, Hyo-Ju Kim, Sung-Phil Baek, Yong-Hyeon Hong, Kwon-Eui Choi, Sun-Mi |
author_sort | Kim, Jung-Eun |
collection | PubMed |
description | BACKGROUND: The causes of chronic fatigue syndrome (CFS) and idiopathic chronic fatigue (ICF) are not clearly known, and there are no definitive treatments for them. Therefore, patients with CFS and ICF are interested in Oriental medicine or complementary and alternative medicine. For this reason, the effectiveness of complementary and alternative treatments should be verified. We investigated the effectiveness of two forms of acupuncture added to usual care for CFS and ICF compared to usual care alone. METHODS: A three-arm parallel, non-blinded, randomized controlled trial was performed in four hospitals. We divided 150 participants into treatment and control groups at the same ratio. The treatment groups (Group A, body acupuncture; Group B, Sa-am acupuncture) received 10 sessions for 4 weeks. The control group (Group C) continued usual care alone. The primary outcome was the Fatigue Severity Scale (FSS) at 5 weeks after randomization. Secondary outcomes were the FSS at 13 weeks and a short form of the Stress Response Inventory (SRI), the Beck Depression Inventory (BDI), the Numeric Rating Scale (NRS), and the EuroQol-5 Dimension (EQ-5D) at 5 and 13 weeks. RESULTS: Group A showed significantly lower FSS scores than Group C at 5 weeks (P = 0.023). SRI scores were significantly lower in the treatment groups than in the control group at 5 (Group A, P = 0.032; B, P <0.001) and 13 weeks (Group A, P = 0.037; B, P <0.001). Group B showed significantly lower BDI scores than Group C at 13 weeks (P = 0.007). NRS scores from the treatment groups were significantly reduced compared to control at 5 (Group A and B, P <0.001) and 13 weeks (Group A, P = 0.011; B, P = 0.002). CONCLUSIONS: Body acupuncture for 4 weeks in addition to usual care may help improve fatigue in CFS and ICF patients. TRIAL REGISTRATION: Clinical Research Information Service (CRIS) KCT0000508; Registered on 12 August 2012. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13063-015-0857-0) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4515016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45150162015-07-26 Acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial Kim, Jung-Eun Seo, Byung-Kwan Choi, Jin-Bong Kim, Hyeong-Jun Kim, Tae-Hun Lee, Min-Hee Kang, Kyung-Won Kim, Joo-Hee Shin, Kyung-Min Lee, Seunghoon Jung, So-Young Kim, Ae-Ran Shin, Mi-Suk Jung, Hee-Jung Park, Hyo-Ju Kim, Sung-Phil Baek, Yong-Hyeon Hong, Kwon-Eui Choi, Sun-Mi Trials Research BACKGROUND: The causes of chronic fatigue syndrome (CFS) and idiopathic chronic fatigue (ICF) are not clearly known, and there are no definitive treatments for them. Therefore, patients with CFS and ICF are interested in Oriental medicine or complementary and alternative medicine. For this reason, the effectiveness of complementary and alternative treatments should be verified. We investigated the effectiveness of two forms of acupuncture added to usual care for CFS and ICF compared to usual care alone. METHODS: A three-arm parallel, non-blinded, randomized controlled trial was performed in four hospitals. We divided 150 participants into treatment and control groups at the same ratio. The treatment groups (Group A, body acupuncture; Group B, Sa-am acupuncture) received 10 sessions for 4 weeks. The control group (Group C) continued usual care alone. The primary outcome was the Fatigue Severity Scale (FSS) at 5 weeks after randomization. Secondary outcomes were the FSS at 13 weeks and a short form of the Stress Response Inventory (SRI), the Beck Depression Inventory (BDI), the Numeric Rating Scale (NRS), and the EuroQol-5 Dimension (EQ-5D) at 5 and 13 weeks. RESULTS: Group A showed significantly lower FSS scores than Group C at 5 weeks (P = 0.023). SRI scores were significantly lower in the treatment groups than in the control group at 5 (Group A, P = 0.032; B, P <0.001) and 13 weeks (Group A, P = 0.037; B, P <0.001). Group B showed significantly lower BDI scores than Group C at 13 weeks (P = 0.007). NRS scores from the treatment groups were significantly reduced compared to control at 5 (Group A and B, P <0.001) and 13 weeks (Group A, P = 0.011; B, P = 0.002). CONCLUSIONS: Body acupuncture for 4 weeks in addition to usual care may help improve fatigue in CFS and ICF patients. TRIAL REGISTRATION: Clinical Research Information Service (CRIS) KCT0000508; Registered on 12 August 2012. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13063-015-0857-0) contains supplementary material, which is available to authorized users. BioMed Central 2015-07-26 /pmc/articles/PMC4515016/ /pubmed/26211002 http://dx.doi.org/10.1186/s13063-015-0857-0 Text en © Kim et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Kim, Jung-Eun Seo, Byung-Kwan Choi, Jin-Bong Kim, Hyeong-Jun Kim, Tae-Hun Lee, Min-Hee Kang, Kyung-Won Kim, Joo-Hee Shin, Kyung-Min Lee, Seunghoon Jung, So-Young Kim, Ae-Ran Shin, Mi-Suk Jung, Hee-Jung Park, Hyo-Ju Kim, Sung-Phil Baek, Yong-Hyeon Hong, Kwon-Eui Choi, Sun-Mi Acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial |
title | Acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial |
title_full | Acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial |
title_fullStr | Acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial |
title_full_unstemmed | Acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial |
title_short | Acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial |
title_sort | acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515016/ https://www.ncbi.nlm.nih.gov/pubmed/26211002 http://dx.doi.org/10.1186/s13063-015-0857-0 |
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