Chemosensitization in non-small cell lung cancer cells by IKK inhibitor occurs via NF-κB and mitochondrial cytochrome c cascade

In this study, we demonstrated with mechanistic evidence that parthenolide, a sesquiterpene lactone, could antagonize paclitaxel-mediated NF-κB nuclear translocation and activation by selectively targeting I-κB kinase (IKK) activity. We also found that parthenolide could target IKK activity and then...

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Detalles Bibliográficos
Autores principales: Jin, Xianqing, Qiu, Lin, Zhang, Dianliang, Zhang, Mingman, Wang, Ziming, Guo, Zhenhua, Deng, Chun, Guo, Chunbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515074/
https://www.ncbi.nlm.nih.gov/pubmed/19067767
http://dx.doi.org/10.1111/j.1582-4934.2008.00601.x

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