A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds**

A copper-catalyzed coupling reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.

Detalles Bibliográficos
Autores principales: Poh, Jian-Siang, Tran, Duc N, Battilocchio, Claudio, Hawkins, Joel M, Ley, Steven V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515080/
https://www.ncbi.nlm.nih.gov/pubmed/26013774
http://dx.doi.org/10.1002/anie.201501538
Descripción
Sumario:A copper-catalyzed coupling reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.

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