A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds**

A copper-catalyzed coupling reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.

Detalles Bibliográficos
Autores principales: Poh, Jian-Siang, Tran, Duc N, Battilocchio, Claudio, Hawkins, Joel M, Ley, Steven V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515080/
https://www.ncbi.nlm.nih.gov/pubmed/26013774
http://dx.doi.org/10.1002/anie.201501538
_version_ 1782382870691577856
author Poh, Jian-Siang
Tran, Duc N
Battilocchio, Claudio
Hawkins, Joel M
Ley, Steven V
author_facet Poh, Jian-Siang
Tran, Duc N
Battilocchio, Claudio
Hawkins, Joel M
Ley, Steven V
author_sort Poh, Jian-Siang
collection PubMed
description A copper-catalyzed coupling reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.
format Online
Article
Text
id pubmed-4515080
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher WILEY-VCH Verlag
record_format MEDLINE/PubMed
spelling pubmed-45150802015-07-31 A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds** Poh, Jian-Siang Tran, Duc N Battilocchio, Claudio Hawkins, Joel M Ley, Steven V Angew Chem Int Ed Engl Communications A copper-catalyzed coupling reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups. WILEY-VCH Verlag 2015-06-26 2015-05-26 /pmc/articles/PMC4515080/ /pubmed/26013774 http://dx.doi.org/10.1002/anie.201501538 Text en © 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Poh, Jian-Siang
Tran, Duc N
Battilocchio, Claudio
Hawkins, Joel M
Ley, Steven V
A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds**
title A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds**
title_full A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds**
title_fullStr A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds**
title_full_unstemmed A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds**
title_short A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds**
title_sort versatile room-temperature route to di- and trisubstituted allenes using flow-generated diazo compounds**
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515080/
https://www.ncbi.nlm.nih.gov/pubmed/26013774
http://dx.doi.org/10.1002/anie.201501538
work_keys_str_mv AT pohjiansiang aversatileroomtemperatureroutetodiandtrisubstitutedallenesusingflowgenerateddiazocompounds
AT tranducn aversatileroomtemperatureroutetodiandtrisubstitutedallenesusingflowgenerateddiazocompounds
AT battilocchioclaudio aversatileroomtemperatureroutetodiandtrisubstitutedallenesusingflowgenerateddiazocompounds
AT hawkinsjoelm aversatileroomtemperatureroutetodiandtrisubstitutedallenesusingflowgenerateddiazocompounds
AT leystevenv aversatileroomtemperatureroutetodiandtrisubstitutedallenesusingflowgenerateddiazocompounds
AT pohjiansiang versatileroomtemperatureroutetodiandtrisubstitutedallenesusingflowgenerateddiazocompounds
AT tranducn versatileroomtemperatureroutetodiandtrisubstitutedallenesusingflowgenerateddiazocompounds
AT battilocchioclaudio versatileroomtemperatureroutetodiandtrisubstitutedallenesusingflowgenerateddiazocompounds
AT hawkinsjoelm versatileroomtemperatureroutetodiandtrisubstitutedallenesusingflowgenerateddiazocompounds
AT leystevenv versatileroomtemperatureroutetodiandtrisubstitutedallenesusingflowgenerateddiazocompounds

Ejemplares similares