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Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design

Protein–protein interactions are difficult therapeutic targets, and inhibiting pathologically relevant interactions without disrupting other essential ones presents an additional challenge. Herein we report how this might be achieved for the potential anticancer target, the TPX2–importin-α interacti...

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Detalles Bibliográficos
Autores principales:	Holvey, Rhian S, Valkov, Eugene, Neal, David, Stewart, Murray, Abell, Chris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2015
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515083/ https://www.ncbi.nlm.nih.gov/pubmed/25899172 http://dx.doi.org/10.1002/cmdc.201500014

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