Structures of the Apo and FAD-Bound Forms of 2-Hydroxybiphenyl 3-monooxygenase (HbpA) Locate Activity Hotspots Identified by Using Directed Evolution

The FAD-dependent monooxygenase HbpA from Pseudomonas azelaica HBP1 catalyses the hydroxylation of 2-hydroxybiphenyl (2HBP) to 2,3-dihydroxybiphenyl (23DHBP). HbpA has been used extensively as a model for studying flavoprotein hydroxylases under process conditions, and has also been subjected to dir...

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Detalles Bibliográficos
Autores principales: Jensen, Chantel N, Mielke, Tamara, Farrugia, Joseph E, Frank, Annika, Man, Henry, Hart, Sam, Turkenburg, Johan P, Grogan, Gideon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
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Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515095/
https://www.ncbi.nlm.nih.gov/pubmed/25737306
http://dx.doi.org/10.1002/cbic.201402701

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