Treatment with 8-OH-modified adenine (TLR7 ligand)-allergen conjugates decreases T helper type 2-oriented murine airway inflammation

A strategy to improve allergen-specific immunotherapy is to employ new adjuvants stably linked to allergens. The study is addressed to evaluate the in vivo and in vitro effects of allergens [natural Dermatophagoides pteronyssinus 2 (nDer p 2) and ovalbumin (OVA)] chemically bound to an 8-OH-modified...

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Detalles Bibliográficos
Autores principales: Nencini, Francesca, Pratesi, Sara, Petroni, Giulia, Filì, Lucia, Cardilicchia, Elisa, Casini, Andrea, Occhiato, Ernesto Giovanni, Calosi, Laura, Bani, Daniele, Romagnani, Sergio, Maggi, Enrico, Parronchi, Paola, Vultaggio, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515136/
https://www.ncbi.nlm.nih.gov/pubmed/25930741
http://dx.doi.org/10.1111/imm.12475

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