Removing reference mapping biases using limited or no genotype data identifies allelic differences in protein binding at disease-associated loci

BACKGROUND: Genetic variation can alter transcriptional regulatory activity contributing to variation in complex traits and risk of disease, but identifying individual variants that affect regulatory activity has been challenging. Quantitative sequence-based experiments such as ChIP-seq and DNase-se...

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Detalles Bibliográficos
Autores principales: Buchkovich, Martin L., Eklund, Karl, Duan, Qing, Li, Yun, Mohlke, Karen L., Furey, Terrence S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515314/
https://www.ncbi.nlm.nih.gov/pubmed/26210163
http://dx.doi.org/10.1186/s12920-015-0117-x

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