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Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum

There is increasing evidence implicating HER3 in several types of cancer. But the development of targeted therapies to inactivate HER3 function has been a challenging endeavor. Its kinase domain functions in allostery not catalysis, and the classical ATP-analog class of tyrosine kinase inhibitors fa...

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Detalles Bibliográficos
Autores principales:	Ruiz-Saenz, Ana, Sandhu, Manbir, Carrasco, Yazmin, Maglathlin, Rebecca L., Taunton, Jack, Moasser, Mark M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515412/ https://www.ncbi.nlm.nih.gov/pubmed/25619841 http://dx.doi.org/10.1038/onc.2014.455

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