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Impact of Inherited Prothrombotic Disorders on the Long-Term Clinical Outcome of Percutaneous Transluminal Angioplasty in Patients with Diabetes

The aim of our study was to analyse inherited thrombotic disorders that influence the long-term outcome of PTA. Methods. Diabetic patients with peripheral arterial disease (PAD) treated by PTA in our centre between 2008 and 2011 were included in the study. Patients were divided into unsuccessful PTA...

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Autores principales: Dubský, Michal, Jirkovská, Alexandra, Pagáčová, Libuše, Bém, Robert, Němcová, Andrea, Fejfarová, Vladimíra, Wosková, Veronika, Jude, Edward B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515498/
https://www.ncbi.nlm.nih.gov/pubmed/26247037
http://dx.doi.org/10.1155/2015/369758
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author Dubský, Michal
Jirkovská, Alexandra
Pagáčová, Libuše
Bém, Robert
Němcová, Andrea
Fejfarová, Vladimíra
Wosková, Veronika
Jude, Edward B.
author_facet Dubský, Michal
Jirkovská, Alexandra
Pagáčová, Libuše
Bém, Robert
Němcová, Andrea
Fejfarová, Vladimíra
Wosková, Veronika
Jude, Edward B.
author_sort Dubský, Michal
collection PubMed
description The aim of our study was to analyse inherited thrombotic disorders that influence the long-term outcome of PTA. Methods. Diabetic patients with peripheral arterial disease (PAD) treated by PTA in our centre between 2008 and 2011 were included in the study. Patients were divided into unsuccessful PTA group (75 patients), successful PTA group (58 patients), and control group (65 patients, with diabetes but no PAD). Diagnosis of inherited thrombotic disorders included mutation in factor V (Leiden), factor II (prothrombin), and mutation in genes for methylenetetrahydrofolate reductase—MTHFR (C677T and A1298C). Results. The genotypic frequency of Leiden allele G1691A was significantly associated with a risk of unsuccessful PTA in comparison with successful PTA group and control group (OR 8.8 (1.1–70.6), p = 0.041, and OR 9.8 (1.2–79.2), p = 0.032, resp.). However, we only observed a trend for the association of the prothrombin allele G20210A and risk of PTA failure. The frequencies of alleles of MTHFR 677 or 1298 did not differ significantly among the groups. Conclusion. Our study showed higher frequency of heterozygous form of Leiden mutation in diabetic patients with unsuccessful outcome of PTA in comparison with patients with successful PTA and diabetic patients without PAD.
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spelling pubmed-45154982015-08-05 Impact of Inherited Prothrombotic Disorders on the Long-Term Clinical Outcome of Percutaneous Transluminal Angioplasty in Patients with Diabetes Dubský, Michal Jirkovská, Alexandra Pagáčová, Libuše Bém, Robert Němcová, Andrea Fejfarová, Vladimíra Wosková, Veronika Jude, Edward B. J Diabetes Res Research Article The aim of our study was to analyse inherited thrombotic disorders that influence the long-term outcome of PTA. Methods. Diabetic patients with peripheral arterial disease (PAD) treated by PTA in our centre between 2008 and 2011 were included in the study. Patients were divided into unsuccessful PTA group (75 patients), successful PTA group (58 patients), and control group (65 patients, with diabetes but no PAD). Diagnosis of inherited thrombotic disorders included mutation in factor V (Leiden), factor II (prothrombin), and mutation in genes for methylenetetrahydrofolate reductase—MTHFR (C677T and A1298C). Results. The genotypic frequency of Leiden allele G1691A was significantly associated with a risk of unsuccessful PTA in comparison with successful PTA group and control group (OR 8.8 (1.1–70.6), p = 0.041, and OR 9.8 (1.2–79.2), p = 0.032, resp.). However, we only observed a trend for the association of the prothrombin allele G20210A and risk of PTA failure. The frequencies of alleles of MTHFR 677 or 1298 did not differ significantly among the groups. Conclusion. Our study showed higher frequency of heterozygous form of Leiden mutation in diabetic patients with unsuccessful outcome of PTA in comparison with patients with successful PTA and diabetic patients without PAD. Hindawi Publishing Corporation 2015 2015-07-13 /pmc/articles/PMC4515498/ /pubmed/26247037 http://dx.doi.org/10.1155/2015/369758 Text en Copyright © 2015 Michal Dubský et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dubský, Michal
Jirkovská, Alexandra
Pagáčová, Libuše
Bém, Robert
Němcová, Andrea
Fejfarová, Vladimíra
Wosková, Veronika
Jude, Edward B.
Impact of Inherited Prothrombotic Disorders on the Long-Term Clinical Outcome of Percutaneous Transluminal Angioplasty in Patients with Diabetes
title Impact of Inherited Prothrombotic Disorders on the Long-Term Clinical Outcome of Percutaneous Transluminal Angioplasty in Patients with Diabetes
title_full Impact of Inherited Prothrombotic Disorders on the Long-Term Clinical Outcome of Percutaneous Transluminal Angioplasty in Patients with Diabetes
title_fullStr Impact of Inherited Prothrombotic Disorders on the Long-Term Clinical Outcome of Percutaneous Transluminal Angioplasty in Patients with Diabetes
title_full_unstemmed Impact of Inherited Prothrombotic Disorders on the Long-Term Clinical Outcome of Percutaneous Transluminal Angioplasty in Patients with Diabetes
title_short Impact of Inherited Prothrombotic Disorders on the Long-Term Clinical Outcome of Percutaneous Transluminal Angioplasty in Patients with Diabetes
title_sort impact of inherited prothrombotic disorders on the long-term clinical outcome of percutaneous transluminal angioplasty in patients with diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515498/
https://www.ncbi.nlm.nih.gov/pubmed/26247037
http://dx.doi.org/10.1155/2015/369758
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