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Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival
Despite significant improvement over recent decades, oesophageal cancer survival rates remain poor. Neoadjuvant chemoradiotherapy followed by oesophageal resection is mainstay of therapy for resectable oesophageal tumours. Operative morbidity and mortality associated with oesophagectomy remain high...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515501/ https://www.ncbi.nlm.nih.gov/pubmed/26246803 http://dx.doi.org/10.1155/2015/518281 |
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author | O'Sullivan, K. E. Hurley, E. T. Hurley, J. P. |
author_facet | O'Sullivan, K. E. Hurley, E. T. Hurley, J. P. |
author_sort | O'Sullivan, K. E. |
collection | PubMed |
description | Despite significant improvement over recent decades, oesophageal cancer survival rates remain poor. Neoadjuvant chemoradiotherapy followed by oesophageal resection is mainstay of therapy for resectable oesophageal tumours. Operative morbidity and mortality associated with oesophagectomy remain high and complications arise in up to 60% of patients. Management strategies have moved towards definitive chemoradiotherapy for a number of tumour sites (head and neck, cervical, and rectal) particularly for squamous pathology. We undertook to perform a review of the current status of morbidity and mortality associated with oesophagectomy, grading systems determining pathologic response, and data from clinical trials managing patients with definitive chemoradiotherapy to inform a discussion on the topic. |
format | Online Article Text |
id | pubmed-4515501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45155012015-08-05 Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival O'Sullivan, K. E. Hurley, E. T. Hurley, J. P. Gastroenterol Res Pract Review Article Despite significant improvement over recent decades, oesophageal cancer survival rates remain poor. Neoadjuvant chemoradiotherapy followed by oesophageal resection is mainstay of therapy for resectable oesophageal tumours. Operative morbidity and mortality associated with oesophagectomy remain high and complications arise in up to 60% of patients. Management strategies have moved towards definitive chemoradiotherapy for a number of tumour sites (head and neck, cervical, and rectal) particularly for squamous pathology. We undertook to perform a review of the current status of morbidity and mortality associated with oesophagectomy, grading systems determining pathologic response, and data from clinical trials managing patients with definitive chemoradiotherapy to inform a discussion on the topic. Hindawi Publishing Corporation 2015 2015-07-13 /pmc/articles/PMC4515501/ /pubmed/26246803 http://dx.doi.org/10.1155/2015/518281 Text en Copyright © 2015 K. E. O'Sullivan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article O'Sullivan, K. E. Hurley, E. T. Hurley, J. P. Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival |
title | Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival |
title_full | Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival |
title_fullStr | Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival |
title_full_unstemmed | Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival |
title_short | Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival |
title_sort | understanding complete pathologic response in oesophageal cancer: implications for management and survival |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515501/ https://www.ncbi.nlm.nih.gov/pubmed/26246803 http://dx.doi.org/10.1155/2015/518281 |
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