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Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population
Objective: To assess the high-sensitivity C-reactive protein (hs-CRP) levels and explore the risk factors for an elevated hs-CRP level. We also provide the clinical utility of CRP to identify subjects with metabolic syndrome (MetS). Methods: Data were drawn from a cross-sectional survey in China. Su...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515719/ https://www.ncbi.nlm.nih.gov/pubmed/26193292 http://dx.doi.org/10.3390/ijerph120708228 |
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author | Sun, Mingxia Zhang, Liying Chen, Shanying Liu, Xinyu Shao, Xiaofei Zou, Hequn |
author_facet | Sun, Mingxia Zhang, Liying Chen, Shanying Liu, Xinyu Shao, Xiaofei Zou, Hequn |
author_sort | Sun, Mingxia |
collection | PubMed |
description | Objective: To assess the high-sensitivity C-reactive protein (hs-CRP) levels and explore the risk factors for an elevated hs-CRP level. We also provide the clinical utility of CRP to identify subjects with metabolic syndrome (MetS). Methods: Data were drawn from a cross-sectional survey in China. Subjects were divided into three subgroups: hs-CRP ≤ 1 mg/L, 1 mg/L < hs-CRP ≤ 3 mg/L and hs-CRP > 3 mg/L. Multiple linear regressions and logistic regression models were used. Results: In the Chinese population, 50.43% subjects had a low hs-CRP level, 30.21% subjects had an intermediate hs-CRP level and 19.36% subjects had an elevated hs-CRP level. Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and urinary albumin to creatinine ratio (ACR) were correlated with log-CRP. In multivariate analysis, relative risks of an elevated CRP level were 2.40 (95% CI 1.44–3.99, p = 0.001), 3.63 (95% CI 2.20–5.98, p < 0.001), 4.23 (95% CI 2.51–7.11, p < 0.001) and 6.23 (95% CI 3.45–11.26, p < 0.001) for subjects with 1, 2, 3, or more than 3 MetS components, respectively. The accurate estimates of the area under the receiver operating characteristic of hs-CRP for MetS was 0.6954 (95% CI, 0.67–0.72). Conclusion: Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and ACR are correlated with log-CRP. The number of MetS components is a significant determinant of elevated CRP levels after adjusted for other potential confounders. |
format | Online Article Text |
id | pubmed-4515719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45157192015-07-28 Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population Sun, Mingxia Zhang, Liying Chen, Shanying Liu, Xinyu Shao, Xiaofei Zou, Hequn Int J Environ Res Public Health Article Objective: To assess the high-sensitivity C-reactive protein (hs-CRP) levels and explore the risk factors for an elevated hs-CRP level. We also provide the clinical utility of CRP to identify subjects with metabolic syndrome (MetS). Methods: Data were drawn from a cross-sectional survey in China. Subjects were divided into three subgroups: hs-CRP ≤ 1 mg/L, 1 mg/L < hs-CRP ≤ 3 mg/L and hs-CRP > 3 mg/L. Multiple linear regressions and logistic regression models were used. Results: In the Chinese population, 50.43% subjects had a low hs-CRP level, 30.21% subjects had an intermediate hs-CRP level and 19.36% subjects had an elevated hs-CRP level. Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and urinary albumin to creatinine ratio (ACR) were correlated with log-CRP. In multivariate analysis, relative risks of an elevated CRP level were 2.40 (95% CI 1.44–3.99, p = 0.001), 3.63 (95% CI 2.20–5.98, p < 0.001), 4.23 (95% CI 2.51–7.11, p < 0.001) and 6.23 (95% CI 3.45–11.26, p < 0.001) for subjects with 1, 2, 3, or more than 3 MetS components, respectively. The accurate estimates of the area under the receiver operating characteristic of hs-CRP for MetS was 0.6954 (95% CI, 0.67–0.72). Conclusion: Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and ACR are correlated with log-CRP. The number of MetS components is a significant determinant of elevated CRP levels after adjusted for other potential confounders. MDPI 2015-07-17 2015-07 /pmc/articles/PMC4515719/ /pubmed/26193292 http://dx.doi.org/10.3390/ijerph120708228 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sun, Mingxia Zhang, Liying Chen, Shanying Liu, Xinyu Shao, Xiaofei Zou, Hequn Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population |
title | Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population |
title_full | Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population |
title_fullStr | Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population |
title_full_unstemmed | Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population |
title_short | Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population |
title_sort | association of c-reactive protein and metabolic disorder in a chinese population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515719/ https://www.ncbi.nlm.nih.gov/pubmed/26193292 http://dx.doi.org/10.3390/ijerph120708228 |
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