Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods

The renal proximal tubule is a main target for drug-induced toxicity. The prediction of proximal tubular toxicity during drug development remains difficult. Any in vitro methods based on induced pluripotent stem cell-derived renal cells had not been developed, so far. Here, we developed a rapid 1-st...

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Detalles Bibliográficos
Autores principales: Kandasamy, Karthikeyan, Chuah, Jacqueline Kai Chin, Su, Ran, Huang, Peng, Eng, Kim Guan, Xiong, Sijing, Li, Yao, Chia, Chun Siang, Loo, Lit-Hsin, Zink, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515747/
https://www.ncbi.nlm.nih.gov/pubmed/26212763
http://dx.doi.org/10.1038/srep12337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515747/
https://www.ncbi.nlm.nih.gov/pubmed/26212763
http://dx.doi.org/10.1038/srep12337

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