Structural prerequisites for G-protein activation by the neurotensin receptor

We previously determined the structure of neurotensin receptor NTSR1 in an active-like conformation with six thermostabilizing mutations bound to the peptide agonist neurotensin. This receptor was unable to activate G proteins, indicating that the mutations restricted NTSR1 to relate agonist binding...

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Detalles Bibliográficos
Autores principales: Krumm, Brian E., White, Jim F., Shah, Priyanka, Grisshammer, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515772/
https://www.ncbi.nlm.nih.gov/pubmed/26205105
http://dx.doi.org/10.1038/ncomms8895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515772/
https://www.ncbi.nlm.nih.gov/pubmed/26205105
http://dx.doi.org/10.1038/ncomms8895

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