Calcium ion-induced formation of β-sheet/-turn structure leading to alteration of osteogenic activity of bone morphogenetic protein-2

Preserving bioactivity of bone morphogenetic protein 2 (BMP-2) still remains a challenge in protein-based therapy. It is not known how Ca(2+) released from extracellular matrix or existing in physiological environment influences bioactivity in situ till now. Here, effects of extracellular Ca(2+) on...

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Detalles Bibliográficos
Autores principales: Zhang, Wenjing, He, Hongyan, Tian, Yu, Gan, Qi, Zhang, Jing, Yuan, Yuan, Liu, Changsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515877/
https://www.ncbi.nlm.nih.gov/pubmed/26212061
http://dx.doi.org/10.1038/srep12694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515877/
https://www.ncbi.nlm.nih.gov/pubmed/26212061
http://dx.doi.org/10.1038/srep12694

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