High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs

Increasing evidence suggests that treatment with online post-dilution haemodiafiltration (HDF) improves clinical outcome in patients with end-stage kidney disease, if compared with haemodialysis (HD). Although the primary analyses of three large randomized controlled trials (RCTs) showed inconclusiv...

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Autores principales: Mostovaya, Ira M., Grooteman, Muriel P.C., Basile, Carlo, Davenport, Andrew, de Roij van Zuijdewijn, Camiel L.M., Wanner, Christoph, Nubé, Menso J., Blankestijn, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Contents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515895/
https://www.ncbi.nlm.nih.gov/pubmed/26251701
http://dx.doi.org/10.1093/ckj/sfv040
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author Mostovaya, Ira M.
Grooteman, Muriel P.C.
Basile, Carlo
Davenport, Andrew
de Roij van Zuijdewijn, Camiel L.M.
Wanner, Christoph
Nubé, Menso J.
Blankestijn, Peter J.
author_facet Mostovaya, Ira M.
Grooteman, Muriel P.C.
Basile, Carlo
Davenport, Andrew
de Roij van Zuijdewijn, Camiel L.M.
Wanner, Christoph
Nubé, Menso J.
Blankestijn, Peter J.
author_sort Mostovaya, Ira M.
collection PubMed
description Increasing evidence suggests that treatment with online post-dilution haemodiafiltration (HDF) improves clinical outcome in patients with end-stage kidney disease, if compared with haemodialysis (HD). Although the primary analyses of three large randomized controlled trials (RCTs) showed inconclusive results, post hoc analyses of these and previous observational studies comparing online post-dilution HDF with HD showed that the risk of overall and cardiovascular mortality is lowest in patients who are treated with high-volume HDF. As such, the magnitude of the convection volume seems crucial and can be considered as the ‘dose’ of HDF. In this narrative review, the relevance of high convection volume in online post-dilution HDF is discussed. In addition, we briefly touch upon some safety and cost issues.
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spelling pubmed-45158952015-08-06 High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs Mostovaya, Ira M. Grooteman, Muriel P.C. Basile, Carlo Davenport, Andrew de Roij van Zuijdewijn, Camiel L.M. Wanner, Christoph Nubé, Menso J. Blankestijn, Peter J. Clin Kidney J Contents Increasing evidence suggests that treatment with online post-dilution haemodiafiltration (HDF) improves clinical outcome in patients with end-stage kidney disease, if compared with haemodialysis (HD). Although the primary analyses of three large randomized controlled trials (RCTs) showed inconclusive results, post hoc analyses of these and previous observational studies comparing online post-dilution HDF with HD showed that the risk of overall and cardiovascular mortality is lowest in patients who are treated with high-volume HDF. As such, the magnitude of the convection volume seems crucial and can be considered as the ‘dose’ of HDF. In this narrative review, the relevance of high convection volume in online post-dilution HDF is discussed. In addition, we briefly touch upon some safety and cost issues. Oxford University Press 2015-08 2015-06-10 /pmc/articles/PMC4515895/ /pubmed/26251701 http://dx.doi.org/10.1093/ckj/sfv040 Text en © The Author 2015. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Contents
Mostovaya, Ira M.
Grooteman, Muriel P.C.
Basile, Carlo
Davenport, Andrew
de Roij van Zuijdewijn, Camiel L.M.
Wanner, Christoph
Nubé, Menso J.
Blankestijn, Peter J.
High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs
title High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs
title_full High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs
title_fullStr High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs
title_full_unstemmed High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs
title_short High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs
title_sort high convection volume in online post-dilution haemodiafiltration: relevance, safety and costs
topic Contents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515895/
https://www.ncbi.nlm.nih.gov/pubmed/26251701
http://dx.doi.org/10.1093/ckj/sfv040
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