Cargando…

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

OBJECTIVES: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches. METHODS: Epigenetically regulated expression of DIO2 was explored by a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bomer, Nils, den Hollander, Wouter, Ramos, Yolande F M, Bos, Steffan D, van der Breggen, Ruud, Lakenberg, Nico, Pepers, Barry A, van Eeden, Annelies E, Darvishan, Arash, Tobi, Elmar W, Duijnisveld, Bouke J, van den Akker, Erik B, Heijmans, Bastiaan T, van Roon-Mom, Willeke MC, Verbeek, Fons J, van Osch, Gerjo J V M, Nelissen, Rob G H H, Slagboom, P Eline, Meulenbelt, Ingrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2015
Materias:	Basic and Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516000/ https://www.ncbi.nlm.nih.gov/pubmed/24695009 http://dx.doi.org/10.1136/annrheumdis-2013-204739

Ejemplares similares

Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice
por: Bomer, Nils, et al.
Publicado: (2016)

Genes Involved in the Osteoarthritis Process Identified through Genome Wide Expression Analysis in Articular Cartilage; the RAAK Study
por: Ramos, Yolande F. M., et al.
Publicado: (2014)

Annotating Transcriptional Effects of Genetic Variants in Disease‐Relevant Tissue: Transcriptome‐Wide Allelic Imbalance in Osteoarthritic Cartilage
por: den Hollander, Wouter, et al.
Publicado: (2019)

Cost-effective HRMA pre-sequence typing of clone libraries; application to phage display selection
por: Pepers, Barry A, et al.
Publicado: (2009)

Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease
por: van Roon-Mom, Willeke MC, et al.
Publicado: (2008)

Antisense Oligonucleotide-Induced Amyloid Precursor Protein Splicing Modulation as a Therapeutic Approach for Dutch-Type Cerebral Amyloid Angiopathy
por: Daoutsali, Elena, et al.
Publicado: (2021)

Targeting Several CAG Expansion Diseases by a Single Antisense Oligonucleotide
por: Evers, Melvin M., et al.
Publicado: (2011)

Selection and characterization of llama single domain antibodies against N-terminal huntingtin
por: Schut, Menno H., et al.
Publicado: (2014)

Making (anti-) sense out of huntingtin levels in Huntington disease
por: Evers, Melvin M, et al.
Publicado: (2015)

Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA
por: Mastrokolias, Anastasios, et al.
Publicado: (2012)

Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates
por: Schut, Menno H., et al.
Publicado: (2017)

Amyloid beta accumulations and enhanced neuronal differentiation in cerebral organoids of Dutch-type cerebral amyloid angiopathy patients
por: Daoutsali, Elena, et al.
Publicado: (2023)

The MID1 Protein: A Promising Therapeutic Target in Huntington’s Disease
por: Heinz, Annika, et al.
Publicado: (2021)

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array
por: Slieker, Roderick C, et al.
Publicado: (2013)

Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis
por: Houtman, Evelyn, et al.
Publicado: (2021)

Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis
por: Coutinho de Almeida, Rodrigo, et al.
Publicado: (2022)

Antisense Oligonucleotide-Mediated Removal of the Polyglutamine Repeat in Spinocerebellar Ataxia Type 3 Mice
por: Toonen, Lodewijk J.A., et al.
Publicado: (2017)

Ataxin-3 Protein and RNA Toxicity in Spinocerebellar Ataxia Type 3: Current Insights and Emerging Therapeutic Strategies
por: Evers, Melvin M., et al.
Publicado: (2013)

RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage
por: Coutinho de Almeida, Rodrigo, et al.
Publicado: (2019)

Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3
por: Toonen, Lodewijk J. A., et al.
Publicado: (2016)

Juvenile‐Onset Huntington Disease Pathophysiology and Neurodevelopment: A Review
por: Bakels, Hannah S., et al.
Publicado: (2021)

Osteopontin and phospho‐SMAD2/3 are associated with calcification of vessels in D‐CAA, an hereditary cerebral amyloid angiopathy
por: Grand Moursel, Laure, et al.
Publicado: (2019)

No Learning Curve of the Direct Superior Approach in Total Hip Arthroplasty
por: Duijnisveld, Bouke J, et al.
Publicado: (2020)

Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility—Towards Identification of Applicable Early OA Biomarkers
por: Ramos, Yolande F. M., et al.
Publicado: (2021)

The potential value of disease-modifying therapy in patients with spinocerebellar ataxia type 1: an early health economic modeling study
por: van Prooije, Teije, et al.
Publicado: (2023)

Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis
por: Tuerlings, Margo, et al.
Publicado: (2021)

REGENERATIVE MEDICINE – INITIATIVE À LA CARTE A remedy to the blood thirsty count Dracula?
por: Konttinen, Yrjö T, et al.
Publicado: (2008)

Human Induced Pluripotent Stem Cell-Based Modelling of Spinocerebellar Ataxias
por: Hommersom, Marina P., et al.
Publicado: (2021)

Post‐mortem 7T MR imaging and neuropathology in middle stage juvenile‐onset Huntington disease: A case report
por: Bakels, Hannah S., et al.
Publicado: (2022)

Therapeutic Strategies for Spinocerebellar Ataxia Type 1
por: Kerkhof, Laurie M. C., et al.
Publicado: (2023)

Genetics, Mechanisms, and Therapeutic Progress in Polyglutamine Spinocerebellar Ataxias
por: Buijsen, Ronald A.M., et al.
Publicado: (2019)

Correction to: The potential value of disease-modifying therapy in patients with spinocerebellar ataxia type 1: an early health economic modeling study
por: van Prooije, Teije, et al.
Publicado: (2023)

Serum fatty acid chain length associates with prevalent symptomatic end-stage osteoarthritis, independent of BMI
por: Meessen, J. M. T. A., et al.
Publicado: (2020)

Mortality and revision rate of cemented and uncemented hemiarthroplasty after hip fracture: an analysis of the Dutch Arthroplasty Register (LROI)
por: Duijnisveld, Bouke J, et al.
Publicado: (2020)

Preparing n-of-1 Antisense Oligonucleotide Treatments for Rare Neurological Diseases in Europe: Genetic, Regulatory, and Ethical Perspectives
por: Synofzik, Matthis, et al.
Publicado: (2022)

Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood
por: Mastrokolias, Anastasios, et al.
Publicado: (2015)

Antisense-Mediated RNA Targeting: Versatile and Expedient Genetic Manipulation in the Brain
por: Zalachoras, Ioannis, et al.
Publicado: (2011)

Pathological characterization of T2*-weighted MRI contrast in the striatum of Huntington’s disease patients
por: Bulk, Marjolein, et al.
Publicado: (2020)

Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia
por: Kenkhuis, Boyd, et al.
Publicado: (2022)

Elucidating Epigenetic Regulation by Identifying Functional cis‐Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage
por: van Hoolwerff, Marcella, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v4lrs2sact02mamt0igdst4ebr