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Evaluation of the therapeutic results of actinic keratosis treated with topical 5% fluorouracil by reflectance confocal laser microscopy: preliminary study

Topical treatment for actinic keratosis with 5% fluorouracil has a recurrence rate of 54% in 12 months of follow-up. This study analyzed thirteen actinic keratoses on the upper limbs through confocal microscopy, at the time of clinical diagnosis and after 4 weeks of treatment with fluorouracil. Afte...

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Autores principales: Ishioka, Priscila, Maia, Marcus, Rodrigues, Sarita Bartholomei, Marta, Alessandra Cristina, Hirata, Sérgio Henrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516112/
https://www.ncbi.nlm.nih.gov/pubmed/26131881
http://dx.doi.org/10.1590/abd1806-4841.20153437
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author Ishioka, Priscila
Maia, Marcus
Rodrigues, Sarita Bartholomei
Marta, Alessandra Cristina
Hirata, Sérgio Henrique
author_facet Ishioka, Priscila
Maia, Marcus
Rodrigues, Sarita Bartholomei
Marta, Alessandra Cristina
Hirata, Sérgio Henrique
author_sort Ishioka, Priscila
collection PubMed
description Topical treatment for actinic keratosis with 5% fluorouracil has a recurrence rate of 54% in 12 months of follow-up. This study analyzed thirteen actinic keratoses on the upper limbs through confocal microscopy, at the time of clinical diagnosis and after 4 weeks of treatment with fluorouracil. After the treatment was established and evidence of clinical cure was achieved, in two of the nine actinic keratoses, confocal microscopy enabled visualization of focal areas of atypical honeycomb pattern in the epidermis indicating therapeutic failure. Preliminary data suggest the use of confocal microscopy as a tool for diagnosis and therapeutic control of actinic keratosis.
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spelling pubmed-45161122015-07-28 Evaluation of the therapeutic results of actinic keratosis treated with topical 5% fluorouracil by reflectance confocal laser microscopy: preliminary study Ishioka, Priscila Maia, Marcus Rodrigues, Sarita Bartholomei Marta, Alessandra Cristina Hirata, Sérgio Henrique An Bras Dermatol Communication Topical treatment for actinic keratosis with 5% fluorouracil has a recurrence rate of 54% in 12 months of follow-up. This study analyzed thirteen actinic keratoses on the upper limbs through confocal microscopy, at the time of clinical diagnosis and after 4 weeks of treatment with fluorouracil. After the treatment was established and evidence of clinical cure was achieved, in two of the nine actinic keratoses, confocal microscopy enabled visualization of focal areas of atypical honeycomb pattern in the epidermis indicating therapeutic failure. Preliminary data suggest the use of confocal microscopy as a tool for diagnosis and therapeutic control of actinic keratosis. Sociedade Brasileira de Dermatologia 2015 /pmc/articles/PMC4516112/ /pubmed/26131881 http://dx.doi.org/10.1590/abd1806-4841.20153437 Text en © 2015 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communication
Ishioka, Priscila
Maia, Marcus
Rodrigues, Sarita Bartholomei
Marta, Alessandra Cristina
Hirata, Sérgio Henrique
Evaluation of the therapeutic results of actinic keratosis treated with topical 5% fluorouracil by reflectance confocal laser microscopy: preliminary study
title Evaluation of the therapeutic results of actinic keratosis treated with topical 5% fluorouracil by reflectance confocal laser microscopy: preliminary study
title_full Evaluation of the therapeutic results of actinic keratosis treated with topical 5% fluorouracil by reflectance confocal laser microscopy: preliminary study
title_fullStr Evaluation of the therapeutic results of actinic keratosis treated with topical 5% fluorouracil by reflectance confocal laser microscopy: preliminary study
title_full_unstemmed Evaluation of the therapeutic results of actinic keratosis treated with topical 5% fluorouracil by reflectance confocal laser microscopy: preliminary study
title_short Evaluation of the therapeutic results of actinic keratosis treated with topical 5% fluorouracil by reflectance confocal laser microscopy: preliminary study
title_sort evaluation of the therapeutic results of actinic keratosis treated with topical 5% fluorouracil by reflectance confocal laser microscopy: preliminary study
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516112/
https://www.ncbi.nlm.nih.gov/pubmed/26131881
http://dx.doi.org/10.1590/abd1806-4841.20153437
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