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Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma
PURPOSE: To analyze the relationship between intraocular pressure (IOP) and the progression of visual field defects in Japanese primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) patients. PATIENTS AND METHODS: The subjects of the study were patients undergoing treatment for POAG o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516176/ https://www.ncbi.nlm.nih.gov/pubmed/26229431 http://dx.doi.org/10.2147/OPTH.S86450 |
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author | Naito, Tomoko Yoshikawa, Keiji Mizoue, Shiro Nanno, Mami Kimura, Tairo Suzumura, Hirotaka Shiraga, Fumio |
author_facet | Naito, Tomoko Yoshikawa, Keiji Mizoue, Shiro Nanno, Mami Kimura, Tairo Suzumura, Hirotaka Shiraga, Fumio |
author_sort | Naito, Tomoko |
collection | PubMed |
description | PURPOSE: To analyze the relationship between intraocular pressure (IOP) and the progression of visual field defects in Japanese primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) patients. PATIENTS AND METHODS: The subjects of the study were patients undergoing treatment for POAG or NTG who had performed visual field tests at least ten times with a Humphrey field analyzer (Swedish interactive thresholding algorithm standard, C30-2 program). The progression of visual field defects was defined by a significantly negative value of the mean deviation slope at the final visual field test during the follow-up period. The relationships between the progression of visual field defects and IOP, as well as other clinical factors, were retrospectively analyzed. RESULTS: A total of 156 eyes of 156 patients were included in the analysis. Significant progression of visual field defects was observed in 70 eyes of 70 patients (44.9%), while no significant progression was evident in 86 eyes of 86 patients (55.1%). The eyes with visual field defect progression had significantly lower baseline IOP (P<0.05), as well as significantly lower IOP reduction rate (P<0.01). The standard deviation of IOP values during follow-up was significantly greater in the eyes with visual field defect progression than in eyes without (P<0.05). CONCLUSION: Reducing IOP is thought to be useful for Japanese POAG or NTG patients to suppress the progression of visual field defects. In NTG, IOP management should take into account not only achieving the target IOP, but also minimizing the fluctuation of IOP during follow-up period. |
format | Online Article Text |
id | pubmed-4516176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45161762015-07-30 Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma Naito, Tomoko Yoshikawa, Keiji Mizoue, Shiro Nanno, Mami Kimura, Tairo Suzumura, Hirotaka Shiraga, Fumio Clin Ophthalmol Original Research PURPOSE: To analyze the relationship between intraocular pressure (IOP) and the progression of visual field defects in Japanese primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) patients. PATIENTS AND METHODS: The subjects of the study were patients undergoing treatment for POAG or NTG who had performed visual field tests at least ten times with a Humphrey field analyzer (Swedish interactive thresholding algorithm standard, C30-2 program). The progression of visual field defects was defined by a significantly negative value of the mean deviation slope at the final visual field test during the follow-up period. The relationships between the progression of visual field defects and IOP, as well as other clinical factors, were retrospectively analyzed. RESULTS: A total of 156 eyes of 156 patients were included in the analysis. Significant progression of visual field defects was observed in 70 eyes of 70 patients (44.9%), while no significant progression was evident in 86 eyes of 86 patients (55.1%). The eyes with visual field defect progression had significantly lower baseline IOP (P<0.05), as well as significantly lower IOP reduction rate (P<0.01). The standard deviation of IOP values during follow-up was significantly greater in the eyes with visual field defect progression than in eyes without (P<0.05). CONCLUSION: Reducing IOP is thought to be useful for Japanese POAG or NTG patients to suppress the progression of visual field defects. In NTG, IOP management should take into account not only achieving the target IOP, but also minimizing the fluctuation of IOP during follow-up period. Dove Medical Press 2015-07-23 /pmc/articles/PMC4516176/ /pubmed/26229431 http://dx.doi.org/10.2147/OPTH.S86450 Text en © 2015 Naito et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Naito, Tomoko Yoshikawa, Keiji Mizoue, Shiro Nanno, Mami Kimura, Tairo Suzumura, Hirotaka Shiraga, Fumio Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma |
title | Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma |
title_full | Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma |
title_fullStr | Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma |
title_full_unstemmed | Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma |
title_short | Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma |
title_sort | relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516176/ https://www.ncbi.nlm.nih.gov/pubmed/26229431 http://dx.doi.org/10.2147/OPTH.S86450 |
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