Cargando…

Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma

PURPOSE: To analyze the relationship between intraocular pressure (IOP) and the progression of visual field defects in Japanese primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) patients. PATIENTS AND METHODS: The subjects of the study were patients undergoing treatment for POAG o...

Descripción completa

Detalles Bibliográficos
Autores principales: Naito, Tomoko, Yoshikawa, Keiji, Mizoue, Shiro, Nanno, Mami, Kimura, Tairo, Suzumura, Hirotaka, Shiraga, Fumio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516176/
https://www.ncbi.nlm.nih.gov/pubmed/26229431
http://dx.doi.org/10.2147/OPTH.S86450
_version_ 1782383023506849792
author Naito, Tomoko
Yoshikawa, Keiji
Mizoue, Shiro
Nanno, Mami
Kimura, Tairo
Suzumura, Hirotaka
Shiraga, Fumio
author_facet Naito, Tomoko
Yoshikawa, Keiji
Mizoue, Shiro
Nanno, Mami
Kimura, Tairo
Suzumura, Hirotaka
Shiraga, Fumio
author_sort Naito, Tomoko
collection PubMed
description PURPOSE: To analyze the relationship between intraocular pressure (IOP) and the progression of visual field defects in Japanese primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) patients. PATIENTS AND METHODS: The subjects of the study were patients undergoing treatment for POAG or NTG who had performed visual field tests at least ten times with a Humphrey field analyzer (Swedish interactive thresholding algorithm standard, C30-2 program). The progression of visual field defects was defined by a significantly negative value of the mean deviation slope at the final visual field test during the follow-up period. The relationships between the progression of visual field defects and IOP, as well as other clinical factors, were retrospectively analyzed. RESULTS: A total of 156 eyes of 156 patients were included in the analysis. Significant progression of visual field defects was observed in 70 eyes of 70 patients (44.9%), while no significant progression was evident in 86 eyes of 86 patients (55.1%). The eyes with visual field defect progression had significantly lower baseline IOP (P<0.05), as well as significantly lower IOP reduction rate (P<0.01). The standard deviation of IOP values during follow-up was significantly greater in the eyes with visual field defect progression than in eyes without (P<0.05). CONCLUSION: Reducing IOP is thought to be useful for Japanese POAG or NTG patients to suppress the progression of visual field defects. In NTG, IOP management should take into account not only achieving the target IOP, but also minimizing the fluctuation of IOP during follow-up period.
format Online
Article
Text
id pubmed-4516176
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-45161762015-07-30 Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma Naito, Tomoko Yoshikawa, Keiji Mizoue, Shiro Nanno, Mami Kimura, Tairo Suzumura, Hirotaka Shiraga, Fumio Clin Ophthalmol Original Research PURPOSE: To analyze the relationship between intraocular pressure (IOP) and the progression of visual field defects in Japanese primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) patients. PATIENTS AND METHODS: The subjects of the study were patients undergoing treatment for POAG or NTG who had performed visual field tests at least ten times with a Humphrey field analyzer (Swedish interactive thresholding algorithm standard, C30-2 program). The progression of visual field defects was defined by a significantly negative value of the mean deviation slope at the final visual field test during the follow-up period. The relationships between the progression of visual field defects and IOP, as well as other clinical factors, were retrospectively analyzed. RESULTS: A total of 156 eyes of 156 patients were included in the analysis. Significant progression of visual field defects was observed in 70 eyes of 70 patients (44.9%), while no significant progression was evident in 86 eyes of 86 patients (55.1%). The eyes with visual field defect progression had significantly lower baseline IOP (P<0.05), as well as significantly lower IOP reduction rate (P<0.01). The standard deviation of IOP values during follow-up was significantly greater in the eyes with visual field defect progression than in eyes without (P<0.05). CONCLUSION: Reducing IOP is thought to be useful for Japanese POAG or NTG patients to suppress the progression of visual field defects. In NTG, IOP management should take into account not only achieving the target IOP, but also minimizing the fluctuation of IOP during follow-up period. Dove Medical Press 2015-07-23 /pmc/articles/PMC4516176/ /pubmed/26229431 http://dx.doi.org/10.2147/OPTH.S86450 Text en © 2015 Naito et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Naito, Tomoko
Yoshikawa, Keiji
Mizoue, Shiro
Nanno, Mami
Kimura, Tairo
Suzumura, Hirotaka
Shiraga, Fumio
Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma
title Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma
title_full Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma
title_fullStr Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma
title_full_unstemmed Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma
title_short Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma
title_sort relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516176/
https://www.ncbi.nlm.nih.gov/pubmed/26229431
http://dx.doi.org/10.2147/OPTH.S86450
work_keys_str_mv AT naitotomoko relationshipbetweenprogressionofvisualfielddefectandintraocularpressureinprimaryopenangleglaucoma
AT yoshikawakeiji relationshipbetweenprogressionofvisualfielddefectandintraocularpressureinprimaryopenangleglaucoma
AT mizoueshiro relationshipbetweenprogressionofvisualfielddefectandintraocularpressureinprimaryopenangleglaucoma
AT nannomami relationshipbetweenprogressionofvisualfielddefectandintraocularpressureinprimaryopenangleglaucoma
AT kimuratairo relationshipbetweenprogressionofvisualfielddefectandintraocularpressureinprimaryopenangleglaucoma
AT suzumurahirotaka relationshipbetweenprogressionofvisualfielddefectandintraocularpressureinprimaryopenangleglaucoma
AT shiragafumio relationshipbetweenprogressionofvisualfielddefectandintraocularpressureinprimaryopenangleglaucoma