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Markers of neurodevelopmental impairments in early-onset psychosis

BACKGROUND: The aim of this study was to assess the association between the clinical and neurobiological markers of neurodevelopmental impairments and early-onset schizophrenia spectrum psychosis. METHODS: A sample of 36 patients with early-onset schizophrenia spectrum psychosis was compared to a co...

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Autores principales: Petruzzelli, Maria Giuseppina, Margari, Lucia, Craig, Francesco, Campa, Maria Gloria, Martinelli, Domenico, Pastore, Adriana, Simone, Marta, Margari, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516349/
https://www.ncbi.nlm.nih.gov/pubmed/26229474
http://dx.doi.org/10.2147/NDT.S83904
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author Petruzzelli, Maria Giuseppina
Margari, Lucia
Craig, Francesco
Campa, Maria Gloria
Martinelli, Domenico
Pastore, Adriana
Simone, Marta
Margari, Francesco
author_facet Petruzzelli, Maria Giuseppina
Margari, Lucia
Craig, Francesco
Campa, Maria Gloria
Martinelli, Domenico
Pastore, Adriana
Simone, Marta
Margari, Francesco
author_sort Petruzzelli, Maria Giuseppina
collection PubMed
description BACKGROUND: The aim of this study was to assess the association between the clinical and neurobiological markers of neurodevelopmental impairments and early-onset schizophrenia spectrum psychosis. METHODS: A sample of 36 patients with early-onset schizophrenia spectrum psychosis was compared to a control sample of 36 patients with migraine. We assessed early childhood neurodevelopmental milestones using a modified version of the General Developmental Scale, general intellectual ability using the Wechsler Intelligence Scale for Children–Revised or Leiter International Performance Scale–Revised for patients with speech and language abnormalities, and neurological soft signs with specific regard to subtle motor impairment. RESULTS: Subjects with early-onset psychosis had a higher rate of impaired social development (P=0.001), learning difficulties (P=0.04), enuresis (P=0.0008), a lower intelligence quotient (P<0.001), and subtle motor impairments (P=0.005) than control subjects. CONCLUSION: We suggest that neurodevelopment in early-onset psychosis is characterized by a global impairment of functional and adaptive skills that manifests from early childhood, rather than a delay or limitation in language and motor development. The current evidence is based on a small sample and should be investigated in larger samples in future research.
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spelling pubmed-45163492015-07-30 Markers of neurodevelopmental impairments in early-onset psychosis Petruzzelli, Maria Giuseppina Margari, Lucia Craig, Francesco Campa, Maria Gloria Martinelli, Domenico Pastore, Adriana Simone, Marta Margari, Francesco Neuropsychiatr Dis Treat Original Research BACKGROUND: The aim of this study was to assess the association between the clinical and neurobiological markers of neurodevelopmental impairments and early-onset schizophrenia spectrum psychosis. METHODS: A sample of 36 patients with early-onset schizophrenia spectrum psychosis was compared to a control sample of 36 patients with migraine. We assessed early childhood neurodevelopmental milestones using a modified version of the General Developmental Scale, general intellectual ability using the Wechsler Intelligence Scale for Children–Revised or Leiter International Performance Scale–Revised for patients with speech and language abnormalities, and neurological soft signs with specific regard to subtle motor impairment. RESULTS: Subjects with early-onset psychosis had a higher rate of impaired social development (P=0.001), learning difficulties (P=0.04), enuresis (P=0.0008), a lower intelligence quotient (P<0.001), and subtle motor impairments (P=0.005) than control subjects. CONCLUSION: We suggest that neurodevelopment in early-onset psychosis is characterized by a global impairment of functional and adaptive skills that manifests from early childhood, rather than a delay or limitation in language and motor development. The current evidence is based on a small sample and should be investigated in larger samples in future research. Dove Medical Press 2015-07-20 /pmc/articles/PMC4516349/ /pubmed/26229474 http://dx.doi.org/10.2147/NDT.S83904 Text en © 2015 Petruzzelli et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Petruzzelli, Maria Giuseppina
Margari, Lucia
Craig, Francesco
Campa, Maria Gloria
Martinelli, Domenico
Pastore, Adriana
Simone, Marta
Margari, Francesco
Markers of neurodevelopmental impairments in early-onset psychosis
title Markers of neurodevelopmental impairments in early-onset psychosis
title_full Markers of neurodevelopmental impairments in early-onset psychosis
title_fullStr Markers of neurodevelopmental impairments in early-onset psychosis
title_full_unstemmed Markers of neurodevelopmental impairments in early-onset psychosis
title_short Markers of neurodevelopmental impairments in early-onset psychosis
title_sort markers of neurodevelopmental impairments in early-onset psychosis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516349/
https://www.ncbi.nlm.nih.gov/pubmed/26229474
http://dx.doi.org/10.2147/NDT.S83904
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