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Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents
A synergistic impact of research in the fields of post-angioplasty restenosis, drug-eluting stents and vascular gene therapy over the past 15 years has shaped the concept of gene-eluting stents. Gene-eluting stents hold promise of overcoming some biological and technical problems inherent to drug-el...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516395/ https://www.ncbi.nlm.nih.gov/pubmed/26225356 http://dx.doi.org/10.4172/2329-9495.1000109 |
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author | Fishbein, Ilia Chorny, Michael Adamo, Richard F Forbes, Scott P Corrales, Ricardo A Alferiev, Ivan S Levy, Robert J |
author_facet | Fishbein, Ilia Chorny, Michael Adamo, Richard F Forbes, Scott P Corrales, Ricardo A Alferiev, Ivan S Levy, Robert J |
author_sort | Fishbein, Ilia |
collection | PubMed |
description | A synergistic impact of research in the fields of post-angioplasty restenosis, drug-eluting stents and vascular gene therapy over the past 15 years has shaped the concept of gene-eluting stents. Gene-eluting stents hold promise of overcoming some biological and technical problems inherent to drug-eluting stent technology. As the field of gene-eluting stents matures it becomes evident that all three main design modules of a gene-eluting stent: a therapeutic transgene, a vector and a delivery system are equally important for accomplishing sustained inhibition of neointimal formation in arteries treated with gene delivery stents. This review summarizes prior work on stent-based gene delivery and discusses the main optimization strategies required to move the field of gene-eluting stents to clinical translation. |
format | Online Article Text |
id | pubmed-4516395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-45163952015-07-27 Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents Fishbein, Ilia Chorny, Michael Adamo, Richard F Forbes, Scott P Corrales, Ricardo A Alferiev, Ivan S Levy, Robert J Angiol Open Access Article A synergistic impact of research in the fields of post-angioplasty restenosis, drug-eluting stents and vascular gene therapy over the past 15 years has shaped the concept of gene-eluting stents. Gene-eluting stents hold promise of overcoming some biological and technical problems inherent to drug-eluting stent technology. As the field of gene-eluting stents matures it becomes evident that all three main design modules of a gene-eluting stent: a therapeutic transgene, a vector and a delivery system are equally important for accomplishing sustained inhibition of neointimal formation in arteries treated with gene delivery stents. This review summarizes prior work on stent-based gene delivery and discusses the main optimization strategies required to move the field of gene-eluting stents to clinical translation. 2013-07-27 2013 /pmc/articles/PMC4516395/ /pubmed/26225356 http://dx.doi.org/10.4172/2329-9495.1000109 Text en Copyright: © 2013 Fishbein I, et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Article Fishbein, Ilia Chorny, Michael Adamo, Richard F Forbes, Scott P Corrales, Ricardo A Alferiev, Ivan S Levy, Robert J Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents |
title | Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents |
title_full | Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents |
title_fullStr | Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents |
title_full_unstemmed | Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents |
title_short | Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents |
title_sort | endovascular gene delivery from a stent platform: gene- eluting stents |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516395/ https://www.ncbi.nlm.nih.gov/pubmed/26225356 http://dx.doi.org/10.4172/2329-9495.1000109 |
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