Cargando…

Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents

A synergistic impact of research in the fields of post-angioplasty restenosis, drug-eluting stents and vascular gene therapy over the past 15 years has shaped the concept of gene-eluting stents. Gene-eluting stents hold promise of overcoming some biological and technical problems inherent to drug-el...

Descripción completa

Detalles Bibliográficos
Autores principales: Fishbein, Ilia, Chorny, Michael, Adamo, Richard F, Forbes, Scott P, Corrales, Ricardo A, Alferiev, Ivan S, Levy, Robert J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516395/
https://www.ncbi.nlm.nih.gov/pubmed/26225356
http://dx.doi.org/10.4172/2329-9495.1000109
_version_ 1782383059741442048
author Fishbein, Ilia
Chorny, Michael
Adamo, Richard F
Forbes, Scott P
Corrales, Ricardo A
Alferiev, Ivan S
Levy, Robert J
author_facet Fishbein, Ilia
Chorny, Michael
Adamo, Richard F
Forbes, Scott P
Corrales, Ricardo A
Alferiev, Ivan S
Levy, Robert J
author_sort Fishbein, Ilia
collection PubMed
description A synergistic impact of research in the fields of post-angioplasty restenosis, drug-eluting stents and vascular gene therapy over the past 15 years has shaped the concept of gene-eluting stents. Gene-eluting stents hold promise of overcoming some biological and technical problems inherent to drug-eluting stent technology. As the field of gene-eluting stents matures it becomes evident that all three main design modules of a gene-eluting stent: a therapeutic transgene, a vector and a delivery system are equally important for accomplishing sustained inhibition of neointimal formation in arteries treated with gene delivery stents. This review summarizes prior work on stent-based gene delivery and discusses the main optimization strategies required to move the field of gene-eluting stents to clinical translation.
format Online
Article
Text
id pubmed-4516395
institution National Center for Biotechnology Information
language English
publishDate 2013
record_format MEDLINE/PubMed
spelling pubmed-45163952015-07-27 Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents Fishbein, Ilia Chorny, Michael Adamo, Richard F Forbes, Scott P Corrales, Ricardo A Alferiev, Ivan S Levy, Robert J Angiol Open Access Article A synergistic impact of research in the fields of post-angioplasty restenosis, drug-eluting stents and vascular gene therapy over the past 15 years has shaped the concept of gene-eluting stents. Gene-eluting stents hold promise of overcoming some biological and technical problems inherent to drug-eluting stent technology. As the field of gene-eluting stents matures it becomes evident that all three main design modules of a gene-eluting stent: a therapeutic transgene, a vector and a delivery system are equally important for accomplishing sustained inhibition of neointimal formation in arteries treated with gene delivery stents. This review summarizes prior work on stent-based gene delivery and discusses the main optimization strategies required to move the field of gene-eluting stents to clinical translation. 2013-07-27 2013 /pmc/articles/PMC4516395/ /pubmed/26225356 http://dx.doi.org/10.4172/2329-9495.1000109 Text en Copyright: © 2013 Fishbein I, et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Fishbein, Ilia
Chorny, Michael
Adamo, Richard F
Forbes, Scott P
Corrales, Ricardo A
Alferiev, Ivan S
Levy, Robert J
Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents
title Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents
title_full Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents
title_fullStr Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents
title_full_unstemmed Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents
title_short Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents
title_sort endovascular gene delivery from a stent platform: gene- eluting stents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516395/
https://www.ncbi.nlm.nih.gov/pubmed/26225356
http://dx.doi.org/10.4172/2329-9495.1000109
work_keys_str_mv AT fishbeinilia endovasculargenedeliveryfromastentplatformgeneelutingstents
AT chornymichael endovasculargenedeliveryfromastentplatformgeneelutingstents
AT adamorichardf endovasculargenedeliveryfromastentplatformgeneelutingstents
AT forbesscottp endovasculargenedeliveryfromastentplatformgeneelutingstents
AT corralesricardoa endovasculargenedeliveryfromastentplatformgeneelutingstents
AT alferievivans endovasculargenedeliveryfromastentplatformgeneelutingstents
AT levyrobertj endovasculargenedeliveryfromastentplatformgeneelutingstents