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Expression of Ca(2+)-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

The second messenger NAADP triggers Ca(2+) release from endo-lysosomes. Although two-pore channels (TPCs) have been proposed to be regulated by NAADP, recent studies have challenged this. By generating the first mouse line with demonstrable absence of both Tpcn1 and Tpcn2 expression (Tpcn1/2(−/−)),...

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Detalles Bibliográficos
Autores principales:	Ruas, Margarida, Davis, Lianne C, Chen, Cheng-Chang, Morgan, Anthony J, Chuang, Kai-Ting, Walseth, Timothy F, Grimm, Christian, Garnham, Clive, Powell, Trevor, Platt, Nick, Platt, Frances M, Biel, Martin, Wahl-Schott, Christian, Parrington, John, Galione, Antony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516428/ https://www.ncbi.nlm.nih.gov/pubmed/25872774 http://dx.doi.org/10.15252/embj.201490009

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