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Presenilin-2 dampens intracellular Ca(2+) stores by increasing Ca(2+) leakage and reducing Ca(2+) uptake

We have previously shown that familial Alzheimer’s disease mutants of presenilin-2 (PS2) and, to a lesser extent, of presenilin-1 (PS1) lower the Ca(2+) concentration of intracellular stores. We here examined the mechanism by which wild-type and mutant PS2 affect store Ca(2+) handling. By using HeLa...

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Detalles Bibliográficos
Autores principales:	Brunello, Lucia, Zampese, Enrico, Florean, Cristina, Pozzan, Tullio, Pizzo, Paola, Fasolato, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2009
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516491/ https://www.ncbi.nlm.nih.gov/pubmed/19382908 http://dx.doi.org/10.1111/j.1582-4934.2009.00755.x

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