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Integrin α(1)β(1) is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo

Connective tissue cell activation is of importance during reactive conditions such as solid tumour growth, wound healing and pannus formation in rheumatoid arthritis. Here, we have compared connective tissue cells of mesenchymal origin in human tissues from these conditions and their normal counterp...

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Autores principales: Rodriguez, Alejandro, Karen, Jakob, Gardner, Humphrey, Gerdin, Bengt, Rubin, Kristofer, Sundberg, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516500/
https://www.ncbi.nlm.nih.gov/pubmed/19397781
http://dx.doi.org/10.1111/j.1582-4934.2008.00638.x
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author Rodriguez, Alejandro
Karen, Jakob
Gardner, Humphrey
Gerdin, Bengt
Rubin, Kristofer
Sundberg, Christian
author_facet Rodriguez, Alejandro
Karen, Jakob
Gardner, Humphrey
Gerdin, Bengt
Rubin, Kristofer
Sundberg, Christian
author_sort Rodriguez, Alejandro
collection PubMed
description Connective tissue cell activation is of importance during reactive conditions such as solid tumour growth, wound healing and pannus formation in rheumatoid arthritis. Here, we have compared connective tissue cells of mesenchymal origin in human tissues from these conditions and their normal counterparts using a panel of cell-type-specific markers. In particular, we investigated variations of integrin expression among connective tissue cell phenotypes. Connective tissue cell populations were defined based on their association with the microvasculature and their expression of activation markers. The phenotype of these cells varied according to the type of pathological connective tissue examined. Our morphological data from human tissues suggested that the α(1)β(1) integrin, a collagen/laminin receptor, is involved in the differentiation of precursor cells into myofibroblasts. To mechanistically investigate this hypothesis, we employed experimental models for carcinoma growth and wound healing utilizing α(1) integrin-deficient mice. The data confirmed that the α(1)β(1) integrin is of importance not only for the differentiation of mesenchymal cells into myofibroblasts but also for the neovascularization and connective tissue organization and emphasize the importance of myofibroblasts in the pathophysiology of tissue repair, inflammation and tumour growth.
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spelling pubmed-45165002015-08-03 Integrin α(1)β(1) is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo Rodriguez, Alejandro Karen, Jakob Gardner, Humphrey Gerdin, Bengt Rubin, Kristofer Sundberg, Christian J Cell Mol Med Tissue Remodeling/Regeneration Connective tissue cell activation is of importance during reactive conditions such as solid tumour growth, wound healing and pannus formation in rheumatoid arthritis. Here, we have compared connective tissue cells of mesenchymal origin in human tissues from these conditions and their normal counterparts using a panel of cell-type-specific markers. In particular, we investigated variations of integrin expression among connective tissue cell phenotypes. Connective tissue cell populations were defined based on their association with the microvasculature and their expression of activation markers. The phenotype of these cells varied according to the type of pathological connective tissue examined. Our morphological data from human tissues suggested that the α(1)β(1) integrin, a collagen/laminin receptor, is involved in the differentiation of precursor cells into myofibroblasts. To mechanistically investigate this hypothesis, we employed experimental models for carcinoma growth and wound healing utilizing α(1) integrin-deficient mice. The data confirmed that the α(1)β(1) integrin is of importance not only for the differentiation of mesenchymal cells into myofibroblasts but also for the neovascularization and connective tissue organization and emphasize the importance of myofibroblasts in the pathophysiology of tissue repair, inflammation and tumour growth. John Wiley & Sons, Ltd 2009-09 2008-12-29 /pmc/articles/PMC4516500/ /pubmed/19397781 http://dx.doi.org/10.1111/j.1582-4934.2008.00638.x Text en © 2008 The Authors Journal compilation © 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
spellingShingle Tissue Remodeling/Regeneration
Rodriguez, Alejandro
Karen, Jakob
Gardner, Humphrey
Gerdin, Bengt
Rubin, Kristofer
Sundberg, Christian
Integrin α(1)β(1) is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo
title Integrin α(1)β(1) is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo
title_full Integrin α(1)β(1) is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo
title_fullStr Integrin α(1)β(1) is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo
title_full_unstemmed Integrin α(1)β(1) is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo
title_short Integrin α(1)β(1) is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo
title_sort integrin α(1)β(1) is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo
topic Tissue Remodeling/Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516500/
https://www.ncbi.nlm.nih.gov/pubmed/19397781
http://dx.doi.org/10.1111/j.1582-4934.2008.00638.x
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