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Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

The pathogenesis of age-related macular degeneration involves chronic oxidative stress, impaired degradation of membranous discs shed from photoreceptor outer segments and accumulation of lysosomal lipofuscin in retinal pigment epithelial (RPE) cells. It has been estimated that a major part of cellu...

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Detalles Bibliográficos
Autores principales:	Ryhänen, Tuomas, Hyttinen, Juha M T, Kopitz, Jürgen, Rilla, Kirsi, Kuusisto, Erkki, Mannermaa, Eliisa, Viiri, Johanna, Holmberg, Carina I, Immonen, Ilkka, Meri, Seppo, Parkkinen, Jussi, Eskelinen, Eeva-Liisa, Uusitalo, Hannu, Salminen, Antero, Kaarniranta, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2009
Materias:	Cell Death
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516511/ https://www.ncbi.nlm.nih.gov/pubmed/19017362 http://dx.doi.org/10.1111/j.1582-4934.2008.00577.x

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