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Blocking neutrophil integrin activation prevents ischemia–reperfusion injury

Neutrophil recruitment, mediated by β2 integrins, combats pyogenic infections but also plays a key role in ischemia–reperfusion injury and other inflammatory disorders. Talin induces allosteric rearrangements in integrins that increase affinity for ligands (activation). Talin also links integrins to...

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Detalles Bibliográficos
Autores principales:	Yago, Tadayuki, Petrich, Brian G., Zhang, Nan, Liu, Zhenghui, Shao, Bojing, Ginsberg, Mark H., McEver, Rodger P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516797/ https://www.ncbi.nlm.nih.gov/pubmed/26169939 http://dx.doi.org/10.1084/jem.20142358

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