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Salivary cortisol response to infant distress in pregnant women with depressive symptoms
The Hypothalamic-Pituitary-Adrenal (HPA) axis has been proposed as a potential underlying biological mechanism linking prenatal depression with adverse offspring outcomes. However, it is unknown whether the reactivity of this system to stress is altered in pregnant women experiencing depression. The...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516861/ https://www.ncbi.nlm.nih.gov/pubmed/25352317 http://dx.doi.org/10.1007/s00737-014-0473-0 |
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author | Murphy, Susannah E. Braithwaite, Elizabeth C. Hubbard, Isabelle Williams, Kate V. Tindall, Elizabeth Holmes, Emily A. Ramchandani, Paul G. |
author_facet | Murphy, Susannah E. Braithwaite, Elizabeth C. Hubbard, Isabelle Williams, Kate V. Tindall, Elizabeth Holmes, Emily A. Ramchandani, Paul G. |
author_sort | Murphy, Susannah E. |
collection | PubMed |
description | The Hypothalamic-Pituitary-Adrenal (HPA) axis has been proposed as a potential underlying biological mechanism linking prenatal depression with adverse offspring outcomes. However, it is unknown whether the reactivity of this system to stress is altered in pregnant women experiencing depression. The objective of this study was to investigate whether salivary cortisol response to a distressed infant film is enhanced in pregnant women with symptoms of depression compared with non-depressed controls. Salivary cortisol and subjective mood responses to the film were measured in 53 primiparous women, between 11 and 18 weeks gestation. Both groups showed similar increases in state anxiety in response to the film, but there was a significantly increased cortisol response in women experiencing symptoms of depression. Depression during pregnancy is associated with increased reactivity of the HPA axis. This is consistent with altered HPA axis functioning being a key mechanism by which prenatal mood disturbance can impact upon fetal development. |
format | Online Article Text |
id | pubmed-4516861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-45168612015-07-28 Salivary cortisol response to infant distress in pregnant women with depressive symptoms Murphy, Susannah E. Braithwaite, Elizabeth C. Hubbard, Isabelle Williams, Kate V. Tindall, Elizabeth Holmes, Emily A. Ramchandani, Paul G. Arch Womens Ment Health Original Article The Hypothalamic-Pituitary-Adrenal (HPA) axis has been proposed as a potential underlying biological mechanism linking prenatal depression with adverse offspring outcomes. However, it is unknown whether the reactivity of this system to stress is altered in pregnant women experiencing depression. The objective of this study was to investigate whether salivary cortisol response to a distressed infant film is enhanced in pregnant women with symptoms of depression compared with non-depressed controls. Salivary cortisol and subjective mood responses to the film were measured in 53 primiparous women, between 11 and 18 weeks gestation. Both groups showed similar increases in state anxiety in response to the film, but there was a significantly increased cortisol response in women experiencing symptoms of depression. Depression during pregnancy is associated with increased reactivity of the HPA axis. This is consistent with altered HPA axis functioning being a key mechanism by which prenatal mood disturbance can impact upon fetal development. Springer Vienna 2014-10-29 2015 /pmc/articles/PMC4516861/ /pubmed/25352317 http://dx.doi.org/10.1007/s00737-014-0473-0 Text en © The Author(s) 2014, corrected publication 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Murphy, Susannah E. Braithwaite, Elizabeth C. Hubbard, Isabelle Williams, Kate V. Tindall, Elizabeth Holmes, Emily A. Ramchandani, Paul G. Salivary cortisol response to infant distress in pregnant women with depressive symptoms |
title | Salivary cortisol response to infant distress in pregnant women with depressive symptoms |
title_full | Salivary cortisol response to infant distress in pregnant women with depressive symptoms |
title_fullStr | Salivary cortisol response to infant distress in pregnant women with depressive symptoms |
title_full_unstemmed | Salivary cortisol response to infant distress in pregnant women with depressive symptoms |
title_short | Salivary cortisol response to infant distress in pregnant women with depressive symptoms |
title_sort | salivary cortisol response to infant distress in pregnant women with depressive symptoms |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516861/ https://www.ncbi.nlm.nih.gov/pubmed/25352317 http://dx.doi.org/10.1007/s00737-014-0473-0 |
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