Double strand break repair by capture of retrotransposon sequences and reverse-transcribed spliced mRNA sequences in mouse zygotes

The CRISPR/Cas system efficiently introduces double strand breaks (DSBs) at a genomic locus specified by a single guide RNA (sgRNA). The DSBs are subsequently repaired through non-homologous end joining (NHEJ) or homologous recombination (HR). Here, we demonstrate that DSBs introduced into mouse zyg...

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Detalles Bibliográficos
Autores principales: Ono, Ryuichi, Ishii, Masayuki, Fujihara, Yoshitaka, Kitazawa, Moe, Usami, Takako, Kaneko-Ishino, Tomoko, Kanno, Jun, Ikawa, Masahito, Ishino, Fumitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516963/
https://www.ncbi.nlm.nih.gov/pubmed/26216318
http://dx.doi.org/10.1038/srep12281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516963/
https://www.ncbi.nlm.nih.gov/pubmed/26216318
http://dx.doi.org/10.1038/srep12281

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