Estimating genetic effect sizes under joint disease-endophenotype models in presence of gene-environment interactions

Effects of genetic variants on the risk of complex diseases estimated from association studies are typically small. Nonetheless, variants may have important effects in presence of specific levels of environmental exposures, and when a trait related to the disease (endophenotype) is either normal or...

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Detalles Bibliográficos
Autores principales: Bureau, Alexandre, Croteau, Jordie, Couture, Christian, Vohl, Marie-Claude, Bouchard, Claude, Pérusse, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516976/
https://www.ncbi.nlm.nih.gov/pubmed/26284107
http://dx.doi.org/10.3389/fgene.2015.00248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516976/
https://www.ncbi.nlm.nih.gov/pubmed/26284107
http://dx.doi.org/10.3389/fgene.2015.00248

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