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Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47(phox) Expression in Rats
The effect of ellagic acid on oxidative stress and hypertension induced by N(ω)-Nitro-l-arginine methyl ester hydrochloride (L-NAME) was investigated. Male Sprague-Dawley rats were administrated with L-NAME (40 mg/kg/day) for five weeks. L-NAME induced high systolic blood pressure (SBP) and increase...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516999/ https://www.ncbi.nlm.nih.gov/pubmed/26133972 http://dx.doi.org/10.3390/nu7075222 |
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author | Berkban, Thewarid Boonprom, Pattanapong Bunbupha, Sarawoot Umka Welbat, Jariya Kukongviriyapan, Upa Kukongviriyapan, Veerapol Pakdeechote, Poungrat Prachaney, Parichat |
author_facet | Berkban, Thewarid Boonprom, Pattanapong Bunbupha, Sarawoot Umka Welbat, Jariya Kukongviriyapan, Upa Kukongviriyapan, Veerapol Pakdeechote, Poungrat Prachaney, Parichat |
author_sort | Berkban, Thewarid |
collection | PubMed |
description | The effect of ellagic acid on oxidative stress and hypertension induced by N(ω)-Nitro-l-arginine methyl ester hydrochloride (L-NAME) was investigated. Male Sprague-Dawley rats were administrated with L-NAME (40 mg/kg/day) for five weeks. L-NAME induced high systolic blood pressure (SBP) and increased heart rate (HR), hindlimb vascular resistance (HVR) and oxidative stress. Concurrent treatment with ellagic acid (7.5 or 15 mg/kg) prevented these alterations. Co-treatment with ellagic acid was associated with up-regulation of endothelial nitric oxide synthase (eNOS) protein production and alleviation of oxidative stress as indicated by decreased superoxide production in the vascular tissue, reduced plasma malondialdehyde levels, reduced NADPH oxidase subunit p47(phox) expression and increased plasma nitrate/nitrite levels. Our results indicate that ellagic acid attenuates hypertension by reducing NADPH oxidase subunit p47(phox) expression, which prevents oxidative stress and restores NO bioavailability. |
format | Online Article Text |
id | pubmed-4516999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45169992015-07-30 Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47(phox) Expression in Rats Berkban, Thewarid Boonprom, Pattanapong Bunbupha, Sarawoot Umka Welbat, Jariya Kukongviriyapan, Upa Kukongviriyapan, Veerapol Pakdeechote, Poungrat Prachaney, Parichat Nutrients Article The effect of ellagic acid on oxidative stress and hypertension induced by N(ω)-Nitro-l-arginine methyl ester hydrochloride (L-NAME) was investigated. Male Sprague-Dawley rats were administrated with L-NAME (40 mg/kg/day) for five weeks. L-NAME induced high systolic blood pressure (SBP) and increased heart rate (HR), hindlimb vascular resistance (HVR) and oxidative stress. Concurrent treatment with ellagic acid (7.5 or 15 mg/kg) prevented these alterations. Co-treatment with ellagic acid was associated with up-regulation of endothelial nitric oxide synthase (eNOS) protein production and alleviation of oxidative stress as indicated by decreased superoxide production in the vascular tissue, reduced plasma malondialdehyde levels, reduced NADPH oxidase subunit p47(phox) expression and increased plasma nitrate/nitrite levels. Our results indicate that ellagic acid attenuates hypertension by reducing NADPH oxidase subunit p47(phox) expression, which prevents oxidative stress and restores NO bioavailability. MDPI 2015-06-30 /pmc/articles/PMC4516999/ /pubmed/26133972 http://dx.doi.org/10.3390/nu7075222 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Berkban, Thewarid Boonprom, Pattanapong Bunbupha, Sarawoot Umka Welbat, Jariya Kukongviriyapan, Upa Kukongviriyapan, Veerapol Pakdeechote, Poungrat Prachaney, Parichat Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47(phox) Expression in Rats |
title | Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47(phox) Expression in Rats |
title_full | Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47(phox) Expression in Rats |
title_fullStr | Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47(phox) Expression in Rats |
title_full_unstemmed | Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47(phox) Expression in Rats |
title_short | Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47(phox) Expression in Rats |
title_sort | ellagic acid prevents l-name-induced hypertension via restoration of enos and p47(phox) expression in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516999/ https://www.ncbi.nlm.nih.gov/pubmed/26133972 http://dx.doi.org/10.3390/nu7075222 |
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