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Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy—tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs...

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Autores principales: Carpentier, Alexandre, Barez, Pierre-Yves, Hamaidia, Malik, Gazon, Hélène, de Brogniez, Alix, Perike, Srikanth, Gillet, Nicolas, Willems, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517122/
https://www.ncbi.nlm.nih.gov/pubmed/26198240
http://dx.doi.org/10.3390/v7072793
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author Carpentier, Alexandre
Barez, Pierre-Yves
Hamaidia, Malik
Gazon, Hélène
de Brogniez, Alix
Perike, Srikanth
Gillet, Nicolas
Willems, Luc
author_facet Carpentier, Alexandre
Barez, Pierre-Yves
Hamaidia, Malik
Gazon, Hélène
de Brogniez, Alix
Perike, Srikanth
Gillet, Nicolas
Willems, Luc
author_sort Carpentier, Alexandre
collection PubMed
description Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy—tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying an integrated provirus. After transcription, the viral genomic RNA undergoes reverse transcription and integration into the chromosomal DNA of a cell from the newly infected host. The virus then replicates by either one of two modes: (i) an infectious cycle by virus budding and infection of new targets and (ii) mitotic division of cells harboring an integrated provirus. HTLV-1 replication initiates a series of mechanisms in the host including antiviral immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to counteract these defense mechanisms allowing continuous persistence in humans.
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spelling pubmed-45171222015-07-28 Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence Carpentier, Alexandre Barez, Pierre-Yves Hamaidia, Malik Gazon, Hélène de Brogniez, Alix Perike, Srikanth Gillet, Nicolas Willems, Luc Viruses Review Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy—tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying an integrated provirus. After transcription, the viral genomic RNA undergoes reverse transcription and integration into the chromosomal DNA of a cell from the newly infected host. The virus then replicates by either one of two modes: (i) an infectious cycle by virus budding and infection of new targets and (ii) mitotic division of cells harboring an integrated provirus. HTLV-1 replication initiates a series of mechanisms in the host including antiviral immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to counteract these defense mechanisms allowing continuous persistence in humans. MDPI 2015-07-07 /pmc/articles/PMC4517122/ /pubmed/26198240 http://dx.doi.org/10.3390/v7072793 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Carpentier, Alexandre
Barez, Pierre-Yves
Hamaidia, Malik
Gazon, Hélène
de Brogniez, Alix
Perike, Srikanth
Gillet, Nicolas
Willems, Luc
Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence
title Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence
title_full Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence
title_fullStr Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence
title_full_unstemmed Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence
title_short Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence
title_sort modes of human t cell leukemia virus type 1 transmission, replication and persistence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517122/
https://www.ncbi.nlm.nih.gov/pubmed/26198240
http://dx.doi.org/10.3390/v7072793
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