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Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy—tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517122/ https://www.ncbi.nlm.nih.gov/pubmed/26198240 http://dx.doi.org/10.3390/v7072793 |
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author | Carpentier, Alexandre Barez, Pierre-Yves Hamaidia, Malik Gazon, Hélène de Brogniez, Alix Perike, Srikanth Gillet, Nicolas Willems, Luc |
author_facet | Carpentier, Alexandre Barez, Pierre-Yves Hamaidia, Malik Gazon, Hélène de Brogniez, Alix Perike, Srikanth Gillet, Nicolas Willems, Luc |
author_sort | Carpentier, Alexandre |
collection | PubMed |
description | Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy—tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying an integrated provirus. After transcription, the viral genomic RNA undergoes reverse transcription and integration into the chromosomal DNA of a cell from the newly infected host. The virus then replicates by either one of two modes: (i) an infectious cycle by virus budding and infection of new targets and (ii) mitotic division of cells harboring an integrated provirus. HTLV-1 replication initiates a series of mechanisms in the host including antiviral immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to counteract these defense mechanisms allowing continuous persistence in humans. |
format | Online Article Text |
id | pubmed-4517122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45171222015-07-28 Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence Carpentier, Alexandre Barez, Pierre-Yves Hamaidia, Malik Gazon, Hélène de Brogniez, Alix Perike, Srikanth Gillet, Nicolas Willems, Luc Viruses Review Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy—tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying an integrated provirus. After transcription, the viral genomic RNA undergoes reverse transcription and integration into the chromosomal DNA of a cell from the newly infected host. The virus then replicates by either one of two modes: (i) an infectious cycle by virus budding and infection of new targets and (ii) mitotic division of cells harboring an integrated provirus. HTLV-1 replication initiates a series of mechanisms in the host including antiviral immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to counteract these defense mechanisms allowing continuous persistence in humans. MDPI 2015-07-07 /pmc/articles/PMC4517122/ /pubmed/26198240 http://dx.doi.org/10.3390/v7072793 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Carpentier, Alexandre Barez, Pierre-Yves Hamaidia, Malik Gazon, Hélène de Brogniez, Alix Perike, Srikanth Gillet, Nicolas Willems, Luc Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence |
title | Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence |
title_full | Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence |
title_fullStr | Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence |
title_full_unstemmed | Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence |
title_short | Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence |
title_sort | modes of human t cell leukemia virus type 1 transmission, replication and persistence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517122/ https://www.ncbi.nlm.nih.gov/pubmed/26198240 http://dx.doi.org/10.3390/v7072793 |
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