The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis

Human T-cell leukemia virus (HTLV)-1 is a human retrovirus and the etiological agent of adult T-cell leukemia/lymphoma (ATLL), a fatal malignancy of CD4/CD25+ T lymphocytes. In recent years, cellular as well as virus-encoded microRNA (miRNA) have been shown to deregulate signaling pathways to favor...

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Autores principales: Moles, Ramona, Nicot, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517134/
https://www.ncbi.nlm.nih.gov/pubmed/26205403
http://dx.doi.org/10.3390/v7072805
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author Moles, Ramona
Nicot, Christophe
author_facet Moles, Ramona
Nicot, Christophe
author_sort Moles, Ramona
collection PubMed
description Human T-cell leukemia virus (HTLV)-1 is a human retrovirus and the etiological agent of adult T-cell leukemia/lymphoma (ATLL), a fatal malignancy of CD4/CD25+ T lymphocytes. In recent years, cellular as well as virus-encoded microRNA (miRNA) have been shown to deregulate signaling pathways to favor virus life cycle. HTLV-1 does not encode miRNA, but several studies have demonstrated that cellular miRNA expression is affected in infected cells. Distinct mechanisms such as transcriptional, epigenetic or interference with miRNA processing machinery have been involved. This article reviews the current knowledge of the role of cellular microRNAs in virus infection, replication, immune escape and pathogenesis of HTLV-1.
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spelling pubmed-45171342015-07-28 The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis Moles, Ramona Nicot, Christophe Viruses Review Human T-cell leukemia virus (HTLV)-1 is a human retrovirus and the etiological agent of adult T-cell leukemia/lymphoma (ATLL), a fatal malignancy of CD4/CD25+ T lymphocytes. In recent years, cellular as well as virus-encoded microRNA (miRNA) have been shown to deregulate signaling pathways to favor virus life cycle. HTLV-1 does not encode miRNA, but several studies have demonstrated that cellular miRNA expression is affected in infected cells. Distinct mechanisms such as transcriptional, epigenetic or interference with miRNA processing machinery have been involved. This article reviews the current knowledge of the role of cellular microRNAs in virus infection, replication, immune escape and pathogenesis of HTLV-1. MDPI 2015-07-20 /pmc/articles/PMC4517134/ /pubmed/26205403 http://dx.doi.org/10.3390/v7072805 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moles, Ramona
Nicot, Christophe
The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis
title The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis
title_full The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis
title_fullStr The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis
title_full_unstemmed The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis
title_short The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis
title_sort emerging role of mirnas in htlv-1 infection and atll pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517134/
https://www.ncbi.nlm.nih.gov/pubmed/26205403
http://dx.doi.org/10.3390/v7072805
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