Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates

The accumulation of protein aggregates is associated with many devastating neurodegenerative diseases and the existence of distinct aggregated morphotypes has been suggested to explain the heterogeneous phenotype reported for these diseases. Thus, the development of molecular probes able to distingu...

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Detalles Bibliográficos
Autores principales: Klingstedt, Therése, Shirani, Hamid, Mahler, Jasmin, Wegenast-Braun, Bettina M, Nyström, Sofie, Goedert, Michel, Jucker, Mathias, Nilsson, K Peter R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517144/
https://www.ncbi.nlm.nih.gov/pubmed/26013403
http://dx.doi.org/10.1002/chem.201500556

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