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Enzymatic Enantioselective Decarboxylative Protonation of Heteroaryl Malonates

The enzyme aryl/alkenyl malonate decarboxylase (AMDase) catalyses the enantioselective decarboxylative protonation (EDP) of a range of disubstituted malonic acids to give homochiral carboxylic acids that are valuable synthetic intermediates. AMDase exhibits a number of advantages over the non-enzyma...

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Detalles Bibliográficos
Autores principales:	Lewin, Ross, Goodall, Mark, Thompson, Mark L, Leigh, James, Breuer, Michael, Baldenius, Kai, Micklefield, Jason
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2015
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517146/ https://www.ncbi.nlm.nih.gov/pubmed/25766433 http://dx.doi.org/10.1002/chem.201406014

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