Cargando…

Chemical Synthesis of Burkholderia Lipid A Modified with Glycosyl Phosphodiester-Linked 4-Amino-4-deoxy-β-l-arabinose and Its Immunomodulatory Potential

Modification of the Lipid A phosphates by positively charged appendages is a part of the survival strategy of numerous opportunistic Gram-negative bacteria. The phosphate groups of the cystic fibrosis adapted Burkholderia Lipid A are abundantly esterified by 4-amino-4-deoxy-β-l-arabinose (β-l-Ara4N)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hollaus, Ralph, Ittig, Simon, Hofinger, Andreas, Haegman, Mira, Beyaert, Rudi, Kosma, Paul, Zamyatina, Alla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2015
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517147/ https://www.ncbi.nlm.nih.gov/pubmed/25630448 http://dx.doi.org/10.1002/chem.201406058

Ejemplares similares

Stereoselective Synthesis of α- and β-l-Ara4N Glycosyl H-Phosphonates and a Neoglycoconjugate Comprising Glycosyl Phosphodiester Linked β-l-Ara4N
por: Hollaus, Ralph, et al.
Publicado: (2016)

Synthesis of Neoglycoconjugates Containing 4-Amino-4-deoxy-l-arabinose Epitopes Corresponding to the Inner Core of Burkholderia and Proteus Lipopolysaccharides
por: Blaukopf, Markus, et al.
Publicado: (2012)

Development of αGlcN(1↔1)αMan-Based Lipid A Mimetics as a Novel Class of Potent Toll-like Receptor 4 Agonists
por: Adanitsch, Florian, et al.
Publicado: (2014)

Synthetic Phosphodiester‐Linked 4‐Amino‐4‐deoxy‐l‐arabinose Derivatives Demonstrate that ArnT is an Inverting Aminoarabinosyl Transferase
por: Olagnon, Charlotte, et al.
Publicado: (2019)

Synthesis of C-glycosyl phosphonate derivatives of 4-amino-4-deoxy-α-ʟ-arabinose
por: Kerner, Lukáš, et al.
Publicado: (2020)

Tailored Modulation of Cellular Pro-inflammatory Responses With Disaccharide Lipid A Mimetics
por: Heine, Holger, et al.
Publicado: (2021)

Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold
por: Garate, Jose Antonio, et al.
Publicado: (2015)

Conformationally Constrained Lipid A Mimetics for Exploration of Structural Basis of TLR4/MD-2 Activation by Lipopolysaccharide
por: Artner, Daniel, et al.
Publicado: (2013)

Burkholderia cenocepacia and Salmonella enterica ArnT proteins that transfer 4-amino-4-deoxy-l-arabinose to lipopolysaccharide share membrane topology and functional amino acids
por: Tavares-Carreón, Faviola, et al.
Publicado: (2015)

Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics
por: Adanitsch, Florian, et al.
Publicado: (2018)

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8
por: Maelfait, Jonathan, et al.
Publicado: (2008)

Exploring Species-Specificity in TLR4/MD-2 Inhibition with Amphiphilic Lipid A Mimicking Glycolipids
por: Borio, Alessio, et al.
Publicado: (2023)

The Pseudomonas aeruginosa Type III Secretion System Has an Exotoxin S/T/Y Independent Pathogenic Role during Acute Lung Infection
por: Galle, Marlies, et al.
Publicado: (2012)

2-Deoxy-2,3-O-isopropylidene-2,4-di-C-methyl-β-l-arabinose
por: Booth, K. Victoria, et al.
Publicado: (2009)

The Arabinose 5-Phosphate Isomerase KdsD Is Required for Virulence in Burkholderia pseudomallei
por: Jenkins, Christopher H., et al.
Publicado: (2023)

Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways
por: Zamyatina, Alla, et al.
Publicado: (2020)

Synthesis of Zwitterionic 1,1′-Glycosylphosphodiester: A Partial Structure of Galactosamine-Modified Francisella Lipid A
por: Baum, David, et al.
Publicado: (2014)

Zwitterionic Phosphodiester-Substituted Neoglycoconjugates as Ligands for Antibodies and Acute Phase Proteins
por: Labrada, Karell Pérez, et al.
Publicado: (2020)

Corrigendum: Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways
por: Zamyatina, Alla, et al.
Publicado: (2021)

Indium-mediated allylation in carbohydrate synthesis: A short and efficient approach towards higher 2-acetamido-2-deoxy sugars
por: Albler, Christopher, et al.
Publicado: (2014)

Effect of ultrasound on the glycosylation reaction of pea protein isolate–arabinose: Structure and emulsifying properties
por: Chen, Xing, et al.
Publicado: (2022)

Phosphodiester models for cleavage of nucleic acids
por: Mikkola, Satu, et al.
Publicado: (2018)

Therapeutic Targeting of TLR4 for Inflammation, Infection, and Cancer: A Perspective for Disaccharide Lipid A Mimetics
por: Heine, Holger, et al.
Publicado: (2022)

Atomistic details of the phosphodiester cleavage of ribonuclease H
por: Elsässer, B, et al.
Publicado: (2011)

CARD14 Signalling Ensures Cell Survival and Cancer Associated Gene Expression in Prostate Cancer Cells
por: Vanneste, Domien, et al.
Publicado: (2022)

Crystal and molecular structure of methyl l-glycero-α-d-manno-heptopyranoside, and synthesis of 1→7 linked l-glycero-d-manno-heptobiose and its methyl α-glycoside
por: Artner, Daniel, et al.
Publicado: (2011)

Metabolism of l-arabinose in plants
por: Kotake, Toshihisa, et al.
Publicado: (2016)

On the mechanism of RNA phosphodiester backbone cleavage in the absence of solvent
por: Riml, Christian, et al.
Publicado: (2015)

Artificial bioconjugates with naturally occurring linkages: the use of phosphodiester
por: Shoji, Takao, et al.
Publicado: (2018)

Fungal arabinan and l-arabinose metabolism
por: Seiboth, Bernhard, et al.
Publicado: (2011)

Correction to: Metabolism of l-arabinose in plants
por: Kotake, Toshihisa, et al.
Publicado: (2018)

Watching DNA polymerase η make a phosphodiester bond
por: Nakamura, Teruya, et al.
Publicado: (2012)

EGFR induces DNA decomposition via phosphodiester bond cleavage
por: Tong, Yongpeng, et al.
Publicado: (2017)

Theoretical and NMR-based Conformational Analysis of Phosphodiester-linked Disaccharides
por: Gerbst, Alexey G., et al.
Publicado: (2017)

The Mechanism of Cleavage of RNA Phosphodiesters by a Gold Nanoparticle Nanozyme
por: Czescik, Joanna, et al.
Publicado: (2021)

The Biosynthesis of D-1,2,4-Butanetriol From d-Arabinose With an Engineered Escherichia coli
por: Wang, Jing, et al.
Publicado: (2022)

2,4,5-Trihydroxy-3-methylacetophenone: A Cellulosic Chromophore as a Case Study of Aromaticity
por: Zwirchmayr, Nele Sophie, et al.
Publicado: (2017)

High resolution 4D HPCH experiment for sequential assignment of (13)C-labeled RNAs via phosphodiester backbone
por: Saxena, Saurabh, et al.
Publicado: (2015)

Lipid A Mimetics Based on Unnatural Disaccharide Scaffold as Potent TLR4 Agonists for Prospective Immunotherapeutics and Adjuvants
por: Strobl, Sebastian, et al.
Publicado: (2022)

Epistatic Interactions in the Arabinose Cis-Regulatory Element
por: Lagator, Mato, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_e45t4knpbapvj2d5a680s6nkr9