Self-Assembly of Disorazole C(1) through a One-Pot Alkyne Metathesis Homodimerization Strategy**

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Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C(2)-symmetric marine-derived bis(lactone) disorazole C(1), a hig...

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Detalles Bibliográficos
Autores principales: Ralston, Kevin J, Ramstadius, H Clinton, Brewster, Richard C, Niblock, Helen S, Hulme, Alison N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517162/
https://www.ncbi.nlm.nih.gov/pubmed/25926364
http://dx.doi.org/10.1002/anie.201501922
Descripción
Sumario:Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C(2)-symmetric marine-derived bis(lactone) disorazole C(1), a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.

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