Self-Assembly of Disorazole C(1) through a One-Pot Alkyne Metathesis Homodimerization Strategy**

Mostrar otras versiones (1)

Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C(2)-symmetric marine-derived bis(lactone) disorazole C(1), a hig...

Descripción completa

Detalles Bibliográficos
Autores principales: Ralston, Kevin J, Ramstadius, H Clinton, Brewster, Richard C, Niblock, Helen S, Hulme, Alison N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517162/
https://www.ncbi.nlm.nih.gov/pubmed/25926364
http://dx.doi.org/10.1002/anie.201501922
_version_ 1782383160243257344
author Ralston, Kevin J
Ramstadius, H Clinton
Brewster, Richard C
Niblock, Helen S
Hulme, Alison N
author_facet Ralston, Kevin J
Ramstadius, H Clinton
Brewster, Richard C
Niblock, Helen S
Hulme, Alison N
author_sort Ralston, Kevin J
collection PubMed
description Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C(2)-symmetric marine-derived bis(lactone) disorazole C(1), a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.
format Online
Article
Text
id pubmed-4517162
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher WILEY-VCH Verlag
record_format MEDLINE/PubMed
spelling pubmed-45171622015-08-04 Self-Assembly of Disorazole C(1) through a One-Pot Alkyne Metathesis Homodimerization Strategy** Ralston, Kevin J Ramstadius, H Clinton Brewster, Richard C Niblock, Helen S Hulme, Alison N Angew Chem Int Ed Engl Communications Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C(2)-symmetric marine-derived bis(lactone) disorazole C(1), a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process. WILEY-VCH Verlag 2015-06-08 2015-04-29 /pmc/articles/PMC4517162/ /pubmed/25926364 http://dx.doi.org/10.1002/anie.201501922 Text en © 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Ralston, Kevin J
Ramstadius, H Clinton
Brewster, Richard C
Niblock, Helen S
Hulme, Alison N
Self-Assembly of Disorazole C(1) through a One-Pot Alkyne Metathesis Homodimerization Strategy**
title Self-Assembly of Disorazole C(1) through a One-Pot Alkyne Metathesis Homodimerization Strategy**
title_full Self-Assembly of Disorazole C(1) through a One-Pot Alkyne Metathesis Homodimerization Strategy**
title_fullStr Self-Assembly of Disorazole C(1) through a One-Pot Alkyne Metathesis Homodimerization Strategy**
title_full_unstemmed Self-Assembly of Disorazole C(1) through a One-Pot Alkyne Metathesis Homodimerization Strategy**
title_short Self-Assembly of Disorazole C(1) through a One-Pot Alkyne Metathesis Homodimerization Strategy**
title_sort self-assembly of disorazole c(1) through a one-pot alkyne metathesis homodimerization strategy**
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517162/
https://www.ncbi.nlm.nih.gov/pubmed/25926364
http://dx.doi.org/10.1002/anie.201501922
work_keys_str_mv AT ralstonkevinj selfassemblyofdisorazolec1throughaonepotalkynemetathesishomodimerizationstrategy
AT ramstadiushclinton selfassemblyofdisorazolec1throughaonepotalkynemetathesishomodimerizationstrategy
AT brewsterrichardc selfassemblyofdisorazolec1throughaonepotalkynemetathesishomodimerizationstrategy
AT niblockhelens selfassemblyofdisorazolec1throughaonepotalkynemetathesishomodimerizationstrategy
AT hulmealisonn selfassemblyofdisorazolec1throughaonepotalkynemetathesishomodimerizationstrategy

Ejemplares similares